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[Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia].
Med Klin (Munich). 1992 Sep 15; 87(9):460-2.MK

Abstract

Lasting normalisation of uric acid levels after treatment of patients with gout and hyperuricaemia with a combination of 300 mg allopurinol and 60 mg benzbromarone A total of 210 patients (163 men, 47 women) with gout and hyperuricaemia was treated for three months with daily doses of 300 mg allopurinol and 60 mg benzbromarone. During the course of treatment, the uric acid levels decreased to 4.3 +/- 1.3 mg/dl in male, and 4.4 +/- 1.3 mg/dl in female patients. Both of these levels differ significantly from the initial levels (p less than 0.001). Three months after discontinuation of treatment, uric acid levels were 5.7 +/- 1.2 mg/dl in women, and 5.9 +/- 1.4 mg/dl in men, levels that again differed significantly from the initial levels (p less than 0.001); both levels were, however, within the therapeutic range of below 6.4 mg/dl.

Authors+Show Affiliations

Matzkies F
Kurparkklinik Bad Neustadt/Saale.

MeSH

AllopurinolBenzbromaroneDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesGoutHumansMaleUric Acid

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1406482

Citation

Matzkies, F. "[Long Lasting Normalization of Uric Acid After Combination Therapy With 300 Mg Allopurinol and 60 Mg Benzbromarone in Patients With Gout and Hyperuricemia]." Medizinische Klinik (Munich, Germany : 1983), vol. 87, no. 9, 1992, pp. 460-2.
Matzkies F. [Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia]. Med Klin (Munich). 1992;87(9):460-2.
Matzkies, F. (1992). [Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia]. Medizinische Klinik (Munich, Germany : 1983), 87(9), 460-2.
Matzkies F. [Long Lasting Normalization of Uric Acid After Combination Therapy With 300 Mg Allopurinol and 60 Mg Benzbromarone in Patients With Gout and Hyperuricemia]. Med Klin (Munich). 1992 Sep 15;87(9):460-2. PubMed PMID: 1406482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia]. A1 - Matzkies,F, PY - 1992/9/15/pubmed PY - 2000/3/22/medline PY - 1992/9/15/entrez SP - 460 EP - 2 JF - Medizinische Klinik (Munich, Germany : 1983) JO - Med Klin (Munich) VL - 87 IS - 9 N2 - Lasting normalisation of uric acid levels after treatment of patients with gout and hyperuricaemia with a combination of 300 mg allopurinol and 60 mg benzbromarone A total of 210 patients (163 men, 47 women) with gout and hyperuricaemia was treated for three months with daily doses of 300 mg allopurinol and 60 mg benzbromarone. During the course of treatment, the uric acid levels decreased to 4.3 +/- 1.3 mg/dl in male, and 4.4 +/- 1.3 mg/dl in female patients. Both of these levels differ significantly from the initial levels (p less than 0.001). Three months after discontinuation of treatment, uric acid levels were 5.7 +/- 1.2 mg/dl in women, and 5.9 +/- 1.4 mg/dl in men, levels that again differed significantly from the initial levels (p less than 0.001); both levels were, however, within the therapeutic range of below 6.4 mg/dl. SN - 0723-5003 UR - https://www.unboundmedicine.com/medline/citation/1406482/[Long_lasting_normalization_of_uric_acid_after_combination_therapy_with_300_mg_allopurinol_and_60_mg_benzbromarone_in_patients_with_gout_and_hyperuricemia]_ DB - PRIME DP - Unbound Medicine ER -