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Nerve conduction studies in amyotrophic lateral sclerosis.
Muscle Nerve. 1992 Oct; 15(10):1111-5.MN

Abstract

Nerve conduction studies (NCS) are an integral part of the evaluation of amyotrophic lateral sclerosis (ALS) patients and are useful in distinguishing ALS from disorders that mimic it. The question often arises whether in the presence of severe atrophy and reduction of the compound muscle action potential amplitude, abnormal conduction velocity (CV), distal latency (DL), or F-wave latency (F) exceeds what can be expected from ALS alone. To determine the limits of abnormality in classic ALS, we prospectively evaluated NCS data from 61 patients who met a strict clinical definition of ALS. We related CV, DL, and F to distal evoked amplitude (AMP) in peroneal (n = 63 observations), median (n = 50), and ulnar (n = 52) nerves. In nerves with reduced AMP, CV rarely fell to less than 80% of the lower limit of normal, and DL and F rarely exceeded 1.25 times the upper limit of normal. Utilizing the entire data set and regression analyses, 95% confidence limits for expected values for CV, F, and DL as a function of AMP were calculated. These limits thus derived suggest criteria for NCS abnormalities in ALS and may be useful in differentiating ALS from other illnesses.

Authors+Show Affiliations

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1406768

Citation

Cornblath, D R., et al. "Nerve Conduction Studies in Amyotrophic Lateral Sclerosis." Muscle & Nerve, vol. 15, no. 10, 1992, pp. 1111-5.
Cornblath DR, Kuncl RW, Mellits ED, et al. Nerve conduction studies in amyotrophic lateral sclerosis. Muscle Nerve. 1992;15(10):1111-5.
Cornblath, D. R., Kuncl, R. W., Mellits, E. D., Quaskey, S. A., Clawson, L., Pestronk, A., & Drachman, D. B. (1992). Nerve conduction studies in amyotrophic lateral sclerosis. Muscle & Nerve, 15(10), 1111-5.
Cornblath DR, et al. Nerve Conduction Studies in Amyotrophic Lateral Sclerosis. Muscle Nerve. 1992;15(10):1111-5. PubMed PMID: 1406768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nerve conduction studies in amyotrophic lateral sclerosis. AU - Cornblath,D R, AU - Kuncl,R W, AU - Mellits,E D, AU - Quaskey,S A, AU - Clawson,L, AU - Pestronk,A, AU - Drachman,D B, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 1111 EP - 5 JF - Muscle & nerve JO - Muscle Nerve VL - 15 IS - 10 N2 - Nerve conduction studies (NCS) are an integral part of the evaluation of amyotrophic lateral sclerosis (ALS) patients and are useful in distinguishing ALS from disorders that mimic it. The question often arises whether in the presence of severe atrophy and reduction of the compound muscle action potential amplitude, abnormal conduction velocity (CV), distal latency (DL), or F-wave latency (F) exceeds what can be expected from ALS alone. To determine the limits of abnormality in classic ALS, we prospectively evaluated NCS data from 61 patients who met a strict clinical definition of ALS. We related CV, DL, and F to distal evoked amplitude (AMP) in peroneal (n = 63 observations), median (n = 50), and ulnar (n = 52) nerves. In nerves with reduced AMP, CV rarely fell to less than 80% of the lower limit of normal, and DL and F rarely exceeded 1.25 times the upper limit of normal. Utilizing the entire data set and regression analyses, 95% confidence limits for expected values for CV, F, and DL as a function of AMP were calculated. These limits thus derived suggest criteria for NCS abnormalities in ALS and may be useful in differentiating ALS from other illnesses. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/1406768/Nerve_conduction_studies_in_amyotrophic_lateral_sclerosis_ DB - PRIME DP - Unbound Medicine ER -