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Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type.
Neurosci Lett. 1992 Aug 03; 142(1):9-12.NL

Abstract

The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.

Authors+Show Affiliations

Gentleman SM
Department of Anatomy, St. Mary's Hospital Medical School, Imperial College Institute of Science Technology and Medicine, London, UK.
Williams B
No affiliation info available
Royston MC
No affiliation info available
Jagoe R
No affiliation info available
Clinton J
No affiliation info available
Perry RH
No affiliation info available
Ince PG
No affiliation info available
Allsop D
No affiliation info available
Polak JM
No affiliation info available
Roberts GW
No affiliation info available

MeSH

AgedAlzheimer DiseaseAmyloid beta-PeptidesDementiaFemaleHumansLewy BodiesMaleReference ValuesTemporal LobeTissue Distribution

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1407727

Citation

Gentleman, S M., et al. "Quantification of Beta A4 Protein Deposition in the Medial Temporal Lobe: a Comparison of Alzheimer's Disease and Senile Dementia of the Lewy Body Type." Neuroscience Letters, vol. 142, no. 1, 1992, pp. 9-12.
Gentleman SM, Williams B, Royston MC, et al. Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. Neurosci Lett. 1992;142(1):9-12.
Gentleman, S. M., Williams, B., Royston, M. C., Jagoe, R., Clinton, J., Perry, R. H., Ince, P. G., Allsop, D., Polak, J. M., & Roberts, G. W. (1992). Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. Neuroscience Letters, 142(1), 9-12.
Gentleman SM, et al. Quantification of Beta A4 Protein Deposition in the Medial Temporal Lobe: a Comparison of Alzheimer's Disease and Senile Dementia of the Lewy Body Type. Neurosci Lett. 1992 Aug 3;142(1):9-12. PubMed PMID: 1407727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. AU - Gentleman,S M, AU - Williams,B, AU - Royston,M C, AU - Jagoe,R, AU - Clinton,J, AU - Perry,R H, AU - Ince,P G, AU - Allsop,D, AU - Polak,J M, AU - Roberts,G W, PY - 1992/8/3/pubmed PY - 1992/8/3/medline PY - 1992/8/3/entrez SP - 9 EP - 12 JF - Neuroscience letters JO - Neurosci Lett VL - 142 IS - 1 N2 - The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/1407727/Quantification_of_beta_A4_protein_deposition_in_the_medial_temporal_lobe:_a_comparison_of_Alzheimer's_disease_and_senile_dementia_of_the_Lewy_body_type_ DB - PRIME DP - Unbound Medicine ER -