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Clorgyline-induced increases in presynaptic DA: changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis.
Pharmacol Biochem Behav 1992; 42(3):421-9PB

Abstract

Microdialysis was used in behaving rats to further characterize the behavioral and regional dopamine (DA) response to the monoamine oxidase (MAO) inhibitor clorgyline and determine how MAO inhibition affects amphetamine (AMPH)-induced changes in behavioral and extracellular DA dynamics. Although clorgyline (4.0 mg/kg) did not significantly alter behavior, it produced prolonged increases in caudate and accumbens extracellular DA and 3MT and corresponding decreases in homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC). Clorgyline pretreatment altered the behavioral response to both low (0.25 mg/kg) and moderate (2.5 mg/kg) doses of AMPH, which was characterized by a shift to more intense forms of stereotype and corresponding decreases in locomotion. The caudate and accumbens DA response to AMPH (0.25 mg/kg) was also significantly augmented, consistent with an increase in AMPH-releasable cytoplasmic DA. Thus, the potentiated DA response in clorgyline-pretreated animals may be responsible for the changes in the stereotypy profile. Possible implications of these observations for the augmented behavioral response observed with repeated AMPH administration are discussed.

Authors+Show Affiliations

Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1409775

Citation

Segal, D S., et al. "Clorgyline-induced Increases in Presynaptic DA: Changes in the Behavioral and Neurochemical Effects of Amphetamine Using in Vivo Microdialysis." Pharmacology, Biochemistry, and Behavior, vol. 42, no. 3, 1992, pp. 421-9.
Segal DS, Kuczenski R, Okuda C. Clorgyline-induced increases in presynaptic DA: changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis. Pharmacol Biochem Behav. 1992;42(3):421-9.
Segal, D. S., Kuczenski, R., & Okuda, C. (1992). Clorgyline-induced increases in presynaptic DA: changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis. Pharmacology, Biochemistry, and Behavior, 42(3), pp. 421-9.
Segal DS, Kuczenski R, Okuda C. Clorgyline-induced Increases in Presynaptic DA: Changes in the Behavioral and Neurochemical Effects of Amphetamine Using in Vivo Microdialysis. Pharmacol Biochem Behav. 1992;42(3):421-9. PubMed PMID: 1409775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clorgyline-induced increases in presynaptic DA: changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis. AU - Segal,D S, AU - Kuczenski,R, AU - Okuda,C, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 421 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 42 IS - 3 N2 - Microdialysis was used in behaving rats to further characterize the behavioral and regional dopamine (DA) response to the monoamine oxidase (MAO) inhibitor clorgyline and determine how MAO inhibition affects amphetamine (AMPH)-induced changes in behavioral and extracellular DA dynamics. Although clorgyline (4.0 mg/kg) did not significantly alter behavior, it produced prolonged increases in caudate and accumbens extracellular DA and 3MT and corresponding decreases in homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC). Clorgyline pretreatment altered the behavioral response to both low (0.25 mg/kg) and moderate (2.5 mg/kg) doses of AMPH, which was characterized by a shift to more intense forms of stereotype and corresponding decreases in locomotion. The caudate and accumbens DA response to AMPH (0.25 mg/kg) was also significantly augmented, consistent with an increase in AMPH-releasable cytoplasmic DA. Thus, the potentiated DA response in clorgyline-pretreated animals may be responsible for the changes in the stereotypy profile. Possible implications of these observations for the augmented behavioral response observed with repeated AMPH administration are discussed. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/1409775/Clorgyline_induced_increases_in_presynaptic_DA:_changes_in_the_behavioral_and_neurochemical_effects_of_amphetamine_using_in_vivo_microdialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(92)90135-3 DB - PRIME DP - Unbound Medicine ER -