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Gastric emptying in infants with gastroesophageal reflux. Ultrasound evaluation before and after cisapride administration.
Scand J Gastroenterol. 1992 Sep; 27(9):799-804.SJ

Abstract

The present study aimed to evaluate gastric emptying in children with gastroesophageal reflux (GER) by means of real-time ultrasonography, on the basis of measurements of the cross-sectional area of the gastric antrum. Twelve children with GER were studied (seven males, five females; age range, 3-13 months) and compared with 12 normal control children (six males, six females; age range, 3-13 months). The diagnosis of GER was confirmed by 24-h esophageal pH-monitoring. The GER patients had a significantly greater antral area than the controls at 90, 105, and 120 min after eating a standard meal (cow's milk formula, 300 ml/m2 body surface area); in addition, final gastric emptying time was significantly greater in the patients than in the controls (145 +/- 36.9 versus 78.7 +/- 19.3 min; p less than 0.0025). After 8 weeks of treatment with cisapride (0.3 ml/kg, three times a day) 24-h esophageal pH-monitoring and ultrasonography studies were repeated in the patients. The total percentage reflux time was significantly lower (p less than 0.038), and ultrasonography showed a decreased antral area at all the various study times, with no significant difference between patients and controls; final gastric emptying time was also significantly lower than before treatment (p less than 0.009). Furthermore, in the GER patients there was a significant correlation between gastric emptying time and the sum of the various reflux times recorded in the 2 h after all meals over the 24 h.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Dept. of Medical Pathology, University of Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1411289

Citation

Carroccio, A, et al. "Gastric Emptying in Infants With Gastroesophageal Reflux. Ultrasound Evaluation Before and After Cisapride Administration." Scandinavian Journal of Gastroenterology, vol. 27, no. 9, 1992, pp. 799-804.
Carroccio A, Iacono G, Li Voti G, et al. Gastric emptying in infants with gastroesophageal reflux. Ultrasound evaluation before and after cisapride administration. Scand J Gastroenterol. 1992;27(9):799-804.
Carroccio, A., Iacono, G., Li Voti, G., Montalto, G., Cavataio, F., Tulone, V., Lorello, D., Kazmierska, I., Acierno, C., & Notarbartolo, A. (1992). Gastric emptying in infants with gastroesophageal reflux. Ultrasound evaluation before and after cisapride administration. Scandinavian Journal of Gastroenterology, 27(9), 799-804.
Carroccio A, et al. Gastric Emptying in Infants With Gastroesophageal Reflux. Ultrasound Evaluation Before and After Cisapride Administration. Scand J Gastroenterol. 1992;27(9):799-804. PubMed PMID: 1411289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric emptying in infants with gastroesophageal reflux. Ultrasound evaluation before and after cisapride administration. AU - Carroccio,A, AU - Iacono,G, AU - Li Voti,G, AU - Montalto,G, AU - Cavataio,F, AU - Tulone,V, AU - Lorello,D, AU - Kazmierska,I, AU - Acierno,C, AU - Notarbartolo,A, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 799 EP - 804 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 27 IS - 9 N2 - The present study aimed to evaluate gastric emptying in children with gastroesophageal reflux (GER) by means of real-time ultrasonography, on the basis of measurements of the cross-sectional area of the gastric antrum. Twelve children with GER were studied (seven males, five females; age range, 3-13 months) and compared with 12 normal control children (six males, six females; age range, 3-13 months). The diagnosis of GER was confirmed by 24-h esophageal pH-monitoring. The GER patients had a significantly greater antral area than the controls at 90, 105, and 120 min after eating a standard meal (cow's milk formula, 300 ml/m2 body surface area); in addition, final gastric emptying time was significantly greater in the patients than in the controls (145 +/- 36.9 versus 78.7 +/- 19.3 min; p less than 0.0025). After 8 weeks of treatment with cisapride (0.3 ml/kg, three times a day) 24-h esophageal pH-monitoring and ultrasonography studies were repeated in the patients. The total percentage reflux time was significantly lower (p less than 0.038), and ultrasonography showed a decreased antral area at all the various study times, with no significant difference between patients and controls; final gastric emptying time was also significantly lower than before treatment (p less than 0.009). Furthermore, in the GER patients there was a significant correlation between gastric emptying time and the sum of the various reflux times recorded in the 2 h after all meals over the 24 h.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/1411289/Gastric_emptying_in_infants_with_gastroesophageal_reflux__Ultrasound_evaluation_before_and_after_cisapride_administration_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529209011187 DB - PRIME DP - Unbound Medicine ER -