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Primitive neuroectodermal tumors of bone and soft tissue. With reference to histologic differentiation in primary or metastatic foci.
Acta Pathol Jpn. 1992 Jul; 42(7):483-93.AP

Abstract

Primitive neuroectodermal tumors (PNET) of the bone and soft tissue were reviewed by immunohistochemistry and partly by morphometry, focusing particularly on histologic changes in recurrent or metastatic foci, in order to elucidate their probable histogenetic relationship with Ewing's sarcoma (ES) and its extraskeletal counterpart (EES). Eleven cases of bone tumor (average patient age; 15.1 yr) and 12 cases of soft tissue tumor (average patient age; 22.1 yr) which disclosed unequivocal Homer-Wright rosettes and/or at least foci of ganglion cell differentiation either in a given primary tumor or metastatic (or recurrent) foci were selected from small round cell tumors primarily categorized as ES or EES. Most of the cases for which follow-up biopsy samples were available disclosed prominent Homer-Wright rosettes in the metastases, whereas the primary tumors showed features of ES and lacked rosettes. In only one case, Homer-Wright rosettes were absent in the metastatic tumor. Most cases had been treated by combined intensive chemotherapy and radiotherapy, which might have influenced cell differentiation. Neural markers (neuron-specific enolase, neurofilament protein and others) were positive in most cases. Three cases with otherwise typical histologic features of ES or EES showed minute foci of ganglion cell differentiation, as confirmed by morphometry and neural markers. These results suggest that ES (or EES) and PNET are histogenetically related, but represent different stages of cell differentiation.

Authors+Show Affiliations

Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1414358

Citation

Ushigome, S, et al. "Primitive Neuroectodermal Tumors of Bone and Soft Tissue. With Reference to Histologic Differentiation in Primary or Metastatic Foci." Acta Pathologica Japonica, vol. 42, no. 7, 1992, pp. 483-93.
Ushigome S, Shimoda T, Nikaido T, et al. Primitive neuroectodermal tumors of bone and soft tissue. With reference to histologic differentiation in primary or metastatic foci. Acta Pathol Jpn. 1992;42(7):483-93.
Ushigome, S., Shimoda, T., Nikaido, T., Nakamori, K., Miyazawa, Y., Shishikura, A., Takakuwa, T., Ubayama, Y., & Spjut, H. J. (1992). Primitive neuroectodermal tumors of bone and soft tissue. With reference to histologic differentiation in primary or metastatic foci. Acta Pathologica Japonica, 42(7), 483-93.
Ushigome S, et al. Primitive Neuroectodermal Tumors of Bone and Soft Tissue. With Reference to Histologic Differentiation in Primary or Metastatic Foci. Acta Pathol Jpn. 1992;42(7):483-93. PubMed PMID: 1414358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumors of bone and soft tissue. With reference to histologic differentiation in primary or metastatic foci. AU - Ushigome,S, AU - Shimoda,T, AU - Nikaido,T, AU - Nakamori,K, AU - Miyazawa,Y, AU - Shishikura,A, AU - Takakuwa,T, AU - Ubayama,Y, AU - Spjut,H J, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 483 EP - 93 JF - Acta pathologica japonica JO - Acta Pathol. Jpn. VL - 42 IS - 7 N2 - Primitive neuroectodermal tumors (PNET) of the bone and soft tissue were reviewed by immunohistochemistry and partly by morphometry, focusing particularly on histologic changes in recurrent or metastatic foci, in order to elucidate their probable histogenetic relationship with Ewing's sarcoma (ES) and its extraskeletal counterpart (EES). Eleven cases of bone tumor (average patient age; 15.1 yr) and 12 cases of soft tissue tumor (average patient age; 22.1 yr) which disclosed unequivocal Homer-Wright rosettes and/or at least foci of ganglion cell differentiation either in a given primary tumor or metastatic (or recurrent) foci were selected from small round cell tumors primarily categorized as ES or EES. Most of the cases for which follow-up biopsy samples were available disclosed prominent Homer-Wright rosettes in the metastases, whereas the primary tumors showed features of ES and lacked rosettes. In only one case, Homer-Wright rosettes were absent in the metastatic tumor. Most cases had been treated by combined intensive chemotherapy and radiotherapy, which might have influenced cell differentiation. Neural markers (neuron-specific enolase, neurofilament protein and others) were positive in most cases. Three cases with otherwise typical histologic features of ES or EES showed minute foci of ganglion cell differentiation, as confirmed by morphometry and neural markers. These results suggest that ES (or EES) and PNET are histogenetically related, but represent different stages of cell differentiation. SN - 0001-6632 UR - https://www.unboundmedicine.com/medline/citation/1414358/Primitive_neuroectodermal_tumors_of_bone_and_soft_tissue__With_reference_to_histologic_differentiation_in_primary_or_metastatic_foci_ L2 - https://medlineplus.gov/bonecancer.html DB - PRIME DP - Unbound Medicine ER -