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Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins.
Am J Clin Nutr 1992; 56(5):895-8AJ

Abstract

The effects of lauric acid (C12:0) on plasma lipids and lipoproteins were compared with the effects of palmitic acid (C16:0) and oleic acid (C18:1) in a metabolic-diet study of 14 men by using liquid-formula diets fed for 3 wk each in random order. Lauric acid was supplied in a synthetic high-lauric oil, palmitic acid was provided by palm oil and oleic acid in oleic-rich sunflower seed oil. The high-lauric oil resulted in higher concentrations of plasma total cholesterol (4.94 +/- 0.75 mmol/L [mean +/- SE]) and LDL cholesterol (3.70 +/- 0.57 mmol/L) when compared with high-oleic sunflower oil (4.44 +/- 0.54 and 3.31 +/- 0.44 mmol/L, respectively), but did not raise total and LDL cholesterol concentrations as much as did palm oil (5.17 +/- 0.65 and 3.93 +/- 0.51 mmol/L, respectively). No differences were noted in plasma triglycerides or HDL cholesterol. Lauric acid raises total and LDL cholesterol concentrations compared with oleic acid, but is not as potent for increasing cholesterol concentrations as is palmitic acid.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Denke MA
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
    Grundy SM
    No affiliation info available

    MeSH

    AdultAgedCholesterolCholesterol, HDLCholesterol, LDLDietary FatsHumansLauric AcidsLipidsLipoproteinsMaleMiddle AgedOleic AcidOleic AcidsPalmitic AcidPalmitic AcidsTriglycerides

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    1415008

    Citation

    Denke, M A., and S M. Grundy. "Comparison of Effects of Lauric Acid and Palmitic Acid On Plasma Lipids and Lipoproteins." The American Journal of Clinical Nutrition, vol. 56, no. 5, 1992, pp. 895-8.
    Denke MA, Grundy SM. Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. Am J Clin Nutr. 1992;56(5):895-8.
    Denke, M. A., & Grundy, S. M. (1992). Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. The American Journal of Clinical Nutrition, 56(5), pp. 895-8.
    Denke MA, Grundy SM. Comparison of Effects of Lauric Acid and Palmitic Acid On Plasma Lipids and Lipoproteins. Am J Clin Nutr. 1992;56(5):895-8. PubMed PMID: 1415008.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. AU - Denke,M A, AU - Grundy,S M, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 895 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 56 IS - 5 N2 - The effects of lauric acid (C12:0) on plasma lipids and lipoproteins were compared with the effects of palmitic acid (C16:0) and oleic acid (C18:1) in a metabolic-diet study of 14 men by using liquid-formula diets fed for 3 wk each in random order. Lauric acid was supplied in a synthetic high-lauric oil, palmitic acid was provided by palm oil and oleic acid in oleic-rich sunflower seed oil. The high-lauric oil resulted in higher concentrations of plasma total cholesterol (4.94 +/- 0.75 mmol/L [mean +/- SE]) and LDL cholesterol (3.70 +/- 0.57 mmol/L) when compared with high-oleic sunflower oil (4.44 +/- 0.54 and 3.31 +/- 0.44 mmol/L, respectively), but did not raise total and LDL cholesterol concentrations as much as did palm oil (5.17 +/- 0.65 and 3.93 +/- 0.51 mmol/L, respectively). No differences were noted in plasma triglycerides or HDL cholesterol. Lauric acid raises total and LDL cholesterol concentrations compared with oleic acid, but is not as potent for increasing cholesterol concentrations as is palmitic acid. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/1415008/Comparison_of_effects_of_lauric_acid_and_palmitic_acid_on_plasma_lipids_and_lipoproteins_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/56.5.895 DB - PRIME DP - Unbound Medicine ER -