Tags

Type your tag names separated by a space and hit enter

Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls.
Arch Dermatol 1992; 128(10):1345-8AD

Abstract

BACKGROUND AND DESIGN

Increases in sebaceous gland activity are often the earliest sign of the approach of puberty in children. These increases have been attributed to increases in the secretion of adrenal androgens, but the supporting data are sparse and are based on measurements of urinary, rather than serum, androgen concentrations. In this study, we examined sebum composition, serum levels of dehydroepiandrosterone sulfate, and pubertal stage in 111 boys and girls, aged 2 to 15 years. Sebum composition was evaluated by measuring the ratio of wax esters/(cholesterol + cholesterol esters), a ratio known to increase with increasing sebaceous gland activity.

RESULTS

Both wax esters/(cholesterol + cholesterol esters) ratios and serum dehydroepiandrosterone sulfate levels began to increase in children 7 to 10 years old. These changes occurred in many children before the appearance of any physical signs of puberty. Wax esters/(cholesterol + cholesterol esters) ratios were correlated with dehydroepiandrosterone sulfate levels in both boys and girls. In prepubertal children, the regression lines passed through the origin. In subjects who were in early or late puberty, the y intercepts of the regression lines had positive values.

CONCLUSION

Adrenal androgens appear to be the major determinants of sebaceous gland activity during the prepubertal period and to be additive to another hormone or hormones during puberty.

Authors+Show Affiliations

Marshall Research Laboratories, Department of Dermatology, University of Iowa College of Medicine, Iowa City 52242.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1417021

Citation

Stewart, M E., et al. "Sebaceous Gland Activity and Serum Dehydroepiandrosterone Sulfate Levels in Boys and Girls." Archives of Dermatology, vol. 128, no. 10, 1992, pp. 1345-8.
Stewart ME, Downing DT, Cook JS, et al. Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol. 1992;128(10):1345-8.
Stewart, M. E., Downing, D. T., Cook, J. S., Hansen, J. R., & Strauss, J. S. (1992). Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Archives of Dermatology, 128(10), pp. 1345-8.
Stewart ME, et al. Sebaceous Gland Activity and Serum Dehydroepiandrosterone Sulfate Levels in Boys and Girls. Arch Dermatol. 1992;128(10):1345-8. PubMed PMID: 1417021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. AU - Stewart,M E, AU - Downing,D T, AU - Cook,J S, AU - Hansen,J R, AU - Strauss,J S, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 1345 EP - 8 JF - Archives of dermatology JO - Arch Dermatol VL - 128 IS - 10 N2 - BACKGROUND AND DESIGN: Increases in sebaceous gland activity are often the earliest sign of the approach of puberty in children. These increases have been attributed to increases in the secretion of adrenal androgens, but the supporting data are sparse and are based on measurements of urinary, rather than serum, androgen concentrations. In this study, we examined sebum composition, serum levels of dehydroepiandrosterone sulfate, and pubertal stage in 111 boys and girls, aged 2 to 15 years. Sebum composition was evaluated by measuring the ratio of wax esters/(cholesterol + cholesterol esters), a ratio known to increase with increasing sebaceous gland activity. RESULTS: Both wax esters/(cholesterol + cholesterol esters) ratios and serum dehydroepiandrosterone sulfate levels began to increase in children 7 to 10 years old. These changes occurred in many children before the appearance of any physical signs of puberty. Wax esters/(cholesterol + cholesterol esters) ratios were correlated with dehydroepiandrosterone sulfate levels in both boys and girls. In prepubertal children, the regression lines passed through the origin. In subjects who were in early or late puberty, the y intercepts of the regression lines had positive values. CONCLUSION: Adrenal androgens appear to be the major determinants of sebaceous gland activity during the prepubertal period and to be additive to another hormone or hormones during puberty. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/1417021/Sebaceous_gland_activity_and_serum_dehydroepiandrosterone_sulfate_levels_in_boys_and_girls_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/128/pg/1345 DB - PRIME DP - Unbound Medicine ER -