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STUDIES ON GASTRIN.
Gut. 1964 Aug; 5:327-41.Gut

Abstract

These three papers present studies on gastrin. The first paper describes a method of biological assay using the rat. The second paper demonstrates that the highest concentration of gastrin-like activity occurs in the antral mucosa, with a clear gradient of concentration of activity down the gut. However, it is to be noted that the total amount of extractable activity is greatest in the duodenum, although the concentration there is less than in the antrum. No activity was detected in the pancreas. The third paper studies the contents of gastrin-like activity in patients with duodenal ulcer and demonstrates higher figures when stenosis is present. Patients with benign gastric ulcer and carcinomata showed results equal to or greater than in those with the average uncomplicated duodenal ulcer. It was noted that two patients with dilated antra both had very low total gastrin-like activity. There was no correlation between total activity and maximal histamine-stimulated output of acid. There was, however, a positive correlation between the insulin-stimulated acid secretion and the total gastrin-like activity in the cases of uncomplicated duodenal ulcers. The clinical studies are still tentative in view of the several variables present, but it seems likely that they will in due course clarify the role of gastrin in the ulcer problem.

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ncbi.nlm.nih.gov
gut.bmj.com
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Authors

LAI SK
No affiliation info available

MeSH

Biological AssayBiomedical ResearchColonDuodenal UlcerDuodenumFreeze DryingGastrectomyGastric MucosaGastrinsHistologyHumansIleumInsulinJejunumPancreasRatsResearchStatistics as TopicStomach NeoplasmsStomach UlcerZollinger-Ellison Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14209916

Citation

LAI, S K.. "STUDIES ON GASTRIN." Gut, vol. 5, 1964, pp. 327-41.
LAI SK. STUDIES ON GASTRIN. Gut. 1964;5:327-41.
LAI, S. K. (1964). STUDIES ON GASTRIN. Gut, 5, 327-41.
LAI SK. STUDIES ON GASTRIN. Gut. 1964;5:327-41. PubMed PMID: 14209916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - STUDIES ON GASTRIN. A1 - LAI,S K, PY - 1964/8/1/pubmed PY - 1964/8/1/medline PY - 1964/8/1/entrez KW - BIOLOGICAL ASSAY KW - CLINICAL RESEARCH KW - COLON KW - DUODENAL ULCER KW - DUODENUM KW - EXPERIMENTAL LAB STUDY KW - FREEZE DRYING KW - GASTRECTOMY KW - GASTRIC MUCOSA KW - GASTRIN KW - HISTOLOGY KW - ILEUM KW - INSULIN KW - JEJUNUM KW - PANCREAS KW - RATS KW - STATISTICS KW - STOMACH NEOPLASMS KW - STOMACH ULCER KW - ZOLLINGER-ELLISON SYNDROME SP - 327 EP - 41 JF - Gut JO - Gut VL - 5 N2 - These three papers present studies on gastrin. The first paper describes a method of biological assay using the rat. The second paper demonstrates that the highest concentration of gastrin-like activity occurs in the antral mucosa, with a clear gradient of concentration of activity down the gut. However, it is to be noted that the total amount of extractable activity is greatest in the duodenum, although the concentration there is less than in the antrum. No activity was detected in the pancreas. The third paper studies the contents of gastrin-like activity in patients with duodenal ulcer and demonstrates higher figures when stenosis is present. Patients with benign gastric ulcer and carcinomata showed results equal to or greater than in those with the average uncomplicated duodenal ulcer. It was noted that two patients with dilated antra both had very low total gastrin-like activity. There was no correlation between total activity and maximal histamine-stimulated output of acid. There was, however, a positive correlation between the insulin-stimulated acid secretion and the total gastrin-like activity in the cases of uncomplicated duodenal ulcers. The clinical studies are still tentative in view of the several variables present, but it seems likely that they will in due course clarify the role of gastrin in the ulcer problem. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/14209916/STUDIES_ON_GASTRIN_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=14209916 DB - PRIME DP - Unbound Medicine ER -