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Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans.
Biomed Pharmacother. 1992; 46(4):161-5.BP

Abstract

Pinaverium bromide is a specific calcium channel blocker used in the treatment of irritable bowel syndrome (IBS) for its spasmolytic activity. The aim of the present study was to evaluate the effect of orally administered pinaverium bromide on jejunal motility and total and segmental colonic transit time in control subjects. Gastrointestinal studies were performed in 10 healthy volunteers (30 +/- 3 years), before and after a treatment phase of 14 days (150 mg/d). Jejunal motility was measured by prolonged manometry (14 h) and colonic transit time by a multiple ingestion, single marker technique. No significant modification of phase III of the migrating motor complexes was demonstrated. On the contrary, a significant (p < 0.01) but weak decrease of the frequency of contraction was found. Unlike previous studies, no decrease of total or segmental colonic transit time was demonstrated.

Authors+Show Affiliations

Service d'Explorations Fonctionnelles, Hôpital-Laennec, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1421047

Citation

Bouchoucha, M, et al. "Effect of Pinaverium Bromide On Jejunal Motility and Colonic Transit Time in Healthy Humans." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 46, no. 4, 1992, pp. 161-5.
Bouchoucha M, Salles JP, Fallet M, et al. Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans. Biomed Pharmacother. 1992;46(4):161-5.
Bouchoucha, M., Salles, J. P., Fallet, M., Frileux, P., Cugnenc, P. H., & Barbier, J. P. (1992). Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 46(4), 161-5.
Bouchoucha M, et al. Effect of Pinaverium Bromide On Jejunal Motility and Colonic Transit Time in Healthy Humans. Biomed Pharmacother. 1992;46(4):161-5. PubMed PMID: 1421047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans. AU - Bouchoucha,M, AU - Salles,J P, AU - Fallet,M, AU - Frileux,P, AU - Cugnenc,P H, AU - Barbier,J P, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 161 EP - 5 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 46 IS - 4 N2 - Pinaverium bromide is a specific calcium channel blocker used in the treatment of irritable bowel syndrome (IBS) for its spasmolytic activity. The aim of the present study was to evaluate the effect of orally administered pinaverium bromide on jejunal motility and total and segmental colonic transit time in control subjects. Gastrointestinal studies were performed in 10 healthy volunteers (30 +/- 3 years), before and after a treatment phase of 14 days (150 mg/d). Jejunal motility was measured by prolonged manometry (14 h) and colonic transit time by a multiple ingestion, single marker technique. No significant modification of phase III of the migrating motor complexes was demonstrated. On the contrary, a significant (p < 0.01) but weak decrease of the frequency of contraction was found. Unlike previous studies, no decrease of total or segmental colonic transit time was demonstrated. SN - 0753-3322 UR - https://www.unboundmedicine.com/medline/citation/1421047/Effect_of_pinaverium_bromide_on_jejunal_motility_and_colonic_transit_time_in_healthy_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0753-3322(92)90024-2 DB - PRIME DP - Unbound Medicine ER -