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Vitamin K status in cystic fibrosis.
Acta Paediatr 1992; 81(9):658-61AP

Abstract

Appearance of PIVKA-II (protein induced by vitamin K absence-II) in serum is a biochemical sign of insufficient vitamin K-dependent carboxylation of prothrombin. Plasma concentrations of PIVKA-II and vitamin K1 were determined in 24 children with cystic fibrosis. Eight were supplemented with vitamin K1. The purpose of the study was to determine the occurrence of vitamin K deficiency in cystic fibrosis and to evaluate the effect of vitamin K supplementation. PIVKA-II was detectable in only one unsupplemented child. In this patient, the concentration of vitamin K1 was below the limit of detection of 60 ng/l. Vitamin K1 levels in the other unsupplemented children were normal (mean 476 ng/l = 1 mmol/l). The supplemented patients showed extremely high levels of vitamin K1 (mean 22445 ng/l = 50 nmol/l). In conclusion, vitamin K deficiency occurs infrequently in cystic fibrosis. Checking the coagulation system is advised, but routine vitamin K supplementation is not recommended. If additional vitamin K is needed, the starting dose should not exceed 1 mg daily.

Authors+Show Affiliations

Department of Paediatrics, University Hospital Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1421902

Citation

Cornelissen, E A., et al. "Vitamin K Status in Cystic Fibrosis." Acta Paediatrica (Oslo, Norway : 1992), vol. 81, no. 9, 1992, pp. 658-61.
Cornelissen EA, van Lieburg AF, Motohara K, et al. Vitamin K status in cystic fibrosis. Acta Paediatr. 1992;81(9):658-61.
Cornelissen, E. A., van Lieburg, A. F., Motohara, K., & van Oostrom, C. G. (1992). Vitamin K status in cystic fibrosis. Acta Paediatrica (Oslo, Norway : 1992), 81(9), pp. 658-61.
Cornelissen EA, et al. Vitamin K Status in Cystic Fibrosis. Acta Paediatr. 1992;81(9):658-61. PubMed PMID: 1421902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K status in cystic fibrosis. AU - Cornelissen,E A, AU - van Lieburg,A F, AU - Motohara,K, AU - van Oostrom,C G, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 658 EP - 61 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 81 IS - 9 N2 - Appearance of PIVKA-II (protein induced by vitamin K absence-II) in serum is a biochemical sign of insufficient vitamin K-dependent carboxylation of prothrombin. Plasma concentrations of PIVKA-II and vitamin K1 were determined in 24 children with cystic fibrosis. Eight were supplemented with vitamin K1. The purpose of the study was to determine the occurrence of vitamin K deficiency in cystic fibrosis and to evaluate the effect of vitamin K supplementation. PIVKA-II was detectable in only one unsupplemented child. In this patient, the concentration of vitamin K1 was below the limit of detection of 60 ng/l. Vitamin K1 levels in the other unsupplemented children were normal (mean 476 ng/l = 1 mmol/l). The supplemented patients showed extremely high levels of vitamin K1 (mean 22445 ng/l = 50 nmol/l). In conclusion, vitamin K deficiency occurs infrequently in cystic fibrosis. Checking the coagulation system is advised, but routine vitamin K supplementation is not recommended. If additional vitamin K is needed, the starting dose should not exceed 1 mg daily. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/1421902/Vitamin_K_status_in_cystic_fibrosis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0803-5253&date=1992&volume=81&issue=9&spage=658 DB - PRIME DP - Unbound Medicine ER -