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Nass use, cigarette smoking, alcohol consumption and risk of oral and oesophageal precancer.
Eur J Cancer B Oral Oncol 1992; 28B(1):29-35EJ

Abstract

In a cross sectional study, conducted in Uzbekistan, an area with a high incidence of oral and oesophageal cancer, 1569 men were interviewed regarding use of nass quid, cigarette smoking and alcohol drinking. All subjects in the study had an oral examination, and oesophagoscopy was performed in 1344 men. Nass use and cigarette smoking emerged as independent risk factors for oral leukoplakia. The prevalence odds ratio (OR) for life-time nass intake equivalent rose from 1.0 in never-users to 5.17 [95% confidence interval (CI), 3.10-8.61] in the highest category; for total pack-years of cigarettes smoked the risk rose from 1.0 in never-smokers to 10.03 (95% CI, 4.9-20.6) in the highest category. There was a significant trend in risk (P < 0.001), for both factors. In the group with oral leukoplakia, the effect of nass use and cigarette smoking appeared to be additive. Cigarette smoking was also found to be an independent risk factor for oesophageal lesions and was significantly associated with chronic oesophagitis. The risk of chronic oesophagitis in the group with the highest pack-years of cigarettes smoked was approximately double that among non-smokers [Odds ratio (OR) = 2.47; 95% CI 1.34-4.56]. There was a weak association between nass use and oesophageal pathology: the highest life-time intake equivalent was associated with an OR of 1.56 (95% CI 1.09-2.23). Alcohol intake was not found to be independently associated with the presence of oral and oesophageal precancerous lesions.

Authors+Show Affiliations

European Institute of Oncology.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1422467

Citation

Evstifeeva, T V., and D G. Zaridze. "Nass Use, Cigarette Smoking, Alcohol Consumption and Risk of Oral and Oesophageal Precancer." European Journal of Cancer. Part B, Oral Oncology, vol. 28B, no. 1, 1992, pp. 29-35.
Evstifeeva TV, Zaridze DG. Nass use, cigarette smoking, alcohol consumption and risk of oral and oesophageal precancer. Eur J Cancer, B, Oral Oncol. 1992;28B(1):29-35.
Evstifeeva, T. V., & Zaridze, D. G. (1992). Nass use, cigarette smoking, alcohol consumption and risk of oral and oesophageal precancer. European Journal of Cancer. Part B, Oral Oncology, 28B(1), pp. 29-35.
Evstifeeva TV, Zaridze DG. Nass Use, Cigarette Smoking, Alcohol Consumption and Risk of Oral and Oesophageal Precancer. Eur J Cancer, B, Oral Oncol. 1992;28B(1):29-35. PubMed PMID: 1422467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nass use, cigarette smoking, alcohol consumption and risk of oral and oesophageal precancer. AU - Evstifeeva,T V, AU - Zaridze,D G, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 29 EP - 35 JF - European journal of cancer. Part B, Oral oncology JO - Eur. J. Cancer, B, Oral Oncol. VL - 28B IS - 1 N2 - In a cross sectional study, conducted in Uzbekistan, an area with a high incidence of oral and oesophageal cancer, 1569 men were interviewed regarding use of nass quid, cigarette smoking and alcohol drinking. All subjects in the study had an oral examination, and oesophagoscopy was performed in 1344 men. Nass use and cigarette smoking emerged as independent risk factors for oral leukoplakia. The prevalence odds ratio (OR) for life-time nass intake equivalent rose from 1.0 in never-users to 5.17 [95% confidence interval (CI), 3.10-8.61] in the highest category; for total pack-years of cigarettes smoked the risk rose from 1.0 in never-smokers to 10.03 (95% CI, 4.9-20.6) in the highest category. There was a significant trend in risk (P < 0.001), for both factors. In the group with oral leukoplakia, the effect of nass use and cigarette smoking appeared to be additive. Cigarette smoking was also found to be an independent risk factor for oesophageal lesions and was significantly associated with chronic oesophagitis. The risk of chronic oesophagitis in the group with the highest pack-years of cigarettes smoked was approximately double that among non-smokers [Odds ratio (OR) = 2.47; 95% CI 1.34-4.56]. There was a weak association between nass use and oesophageal pathology: the highest life-time intake equivalent was associated with an OR of 1.56 (95% CI 1.09-2.23). Alcohol intake was not found to be independently associated with the presence of oral and oesophageal precancerous lesions. SN - 0964-1955 UR - https://www.unboundmedicine.com/medline/citation/1422467/Nass_use_cigarette_smoking_alcohol_consumption_and_risk_of_oral_and_oesophageal_precancer_ L2 - https://medlineplus.gov/alcohol.html DB - PRIME DP - Unbound Medicine ER -