[Importance of hypergastrinemia in diagnosis of Biermer's disease in adults].
Bull Acad Natl Med. 1992 May; 176(5):693-700.BA

Abstract

Achlorhydria that is due to antrum sparing atrophic gastritis is a characteristic finding in pernicious anemia. As a consequence of this achlorhydria serum gastrin level rise. Usually several signs are required for assessing a pernicious anemia: megaloblastic anemia, low serum cobalamin level, positivity of a Schilling test, low level of intrinsic factor in the gastric juice, existence of anti-intrinsic factor antibodies in plasma and/or in gastric juice. In this study the usefulness of the serum gastrin level is assessed. We report here the results in investigating sixteen patients with a pernicious anemia. All had: megaloblastic changes on bone marrow examination, serum cobalamin level lower than 150 pg/ml. For 14 patients the performed Schilling test was positive. For 2, no Schilling test was done, but anti-intrinsic factor antibodies were elevated. Serum gastrin levels were higher than 250 pg/ml (254 to 1770 pg/ml). In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlohydria: anti-acid treatment, vagotomy... Measurement of serum gastrin is easy. High levels are simple to explain if found together with a sparing antrum atrophic gastritis and/or a low level of serum cobalamin. Serum gastrin measurement may be a cornerstone to rapid and reliable diagnosis of pernicious anemia.

Authors+Show Affiliations

Mongin M

Groupe Hospitalier de la Timone Adultes, Marseille.

Harle JR

No affiliation info available

Weiller PJ

No affiliation info available

MeSH

AdultAnemia, PerniciousGastrinsHumans

Pub Type(s)

English Abstract

Journal Article

Language

fre

PubMed ID

1422872

Citation

Mongin, M, et al. "[Importance of Hypergastrinemia in Diagnosis of Biermer's Disease in Adults]." Bulletin De l'Academie Nationale De Medecine, vol. 176, no. 5, 1992, pp. 693-700.

Mongin M, Harle JR, Weiller PJ. [Importance of hypergastrinemia in diagnosis of Biermer's disease in adults]. Bull Acad Natl Med. 1992;176(5):693-700.

Mongin, M., Harle, J. R., & Weiller, P. J. (1992). [Importance of hypergastrinemia in diagnosis of Biermer's disease in adults]. Bulletin De l'Academie Nationale De Medecine, 176(5), 693-700.

Mongin M, Harle JR, Weiller PJ. [Importance of Hypergastrinemia in Diagnosis of Biermer's Disease in Adults]. Bull Acad Natl Med. 1992;176(5):693-700. PubMed PMID: 1422872.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Importance of hypergastrinemia in diagnosis of Biermer's disease in adults]. AU - Mongin,M, AU - Harle,J R, AU - Weiller,P J, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 693 EP - 700 JF - Bulletin de l'Academie nationale de medecine JO - Bull Acad Natl Med VL - 176 IS - 5 N2 - Achlorhydria that is due to antrum sparing atrophic gastritis is a characteristic finding in pernicious anemia. As a consequence of this achlorhydria serum gastrin level rise. Usually several signs are required for assessing a pernicious anemia: megaloblastic anemia, low serum cobalamin level, positivity of a Schilling test, low level of intrinsic factor in the gastric juice, existence of anti-intrinsic factor antibodies in plasma and/or in gastric juice. In this study the usefulness of the serum gastrin level is assessed. We report here the results in investigating sixteen patients with a pernicious anemia. All had: megaloblastic changes on bone marrow examination, serum cobalamin level lower than 150 pg/ml. For 14 patients the performed Schilling test was positive. For 2, no Schilling test was done, but anti-intrinsic factor antibodies were elevated. Serum gastrin levels were higher than 250 pg/ml (254 to 1770 pg/ml). In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlohydria: anti-acid treatment, vagotomy... Measurement of serum gastrin is easy. High levels are simple to explain if found together with a sparing antrum atrophic gastritis and/or a low level of serum cobalamin. Serum gastrin measurement may be a cornerstone to rapid and reliable diagnosis of pernicious anemia. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/1422872/[Importance_of_hypergastrinemia_in_diagnosis_of_Biermer's_disease_in_adults]_ DB - PRIME DP - Unbound Medicine ER -

Tags

[Importance of hypergastrinemia in diagnosis of Biermer's disease in adults].Bull Acad Natl Med. 1992 May; 176(5):693-700.BA