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Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.
Environ Mol Mutagen. 1992; 20(4):307-12.EM

Abstract

Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2-aminoanthracene, aflatoxin B1 (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively.

Authors+Show Affiliations

Chulasiri M
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Bunyapraphatsara N
No affiliation info available
Moongkarndi P
No affiliation info available

MeSH

Aflatoxin B1AnthracenesAntimutagenic AgentsAzidesCell SurvivalDimethylnitrosamineFlavonesFlavonoidsMicrosomes, LiverMutagenicity TestsMutagensSalmonella typhimuriumSodium AzideSuppression, GeneticThiophenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1425610

Citation

Chulasiri, M, et al. "Mutagenicity and Antimutagenicity of Hispidulin and Hortensin, the Flavonoids From Millingtonia Hortensis L." Environmental and Molecular Mutagenesis, vol. 20, no. 4, 1992, pp. 307-12.
Chulasiri M, Bunyapraphatsara N, Moongkarndi P. Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. Environ Mol Mutagen. 1992;20(4):307-12.
Chulasiri, M., Bunyapraphatsara, N., & Moongkarndi, P. (1992). Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. Environmental and Molecular Mutagenesis, 20(4), 307-12.
Chulasiri M, Bunyapraphatsara N, Moongkarndi P. Mutagenicity and Antimutagenicity of Hispidulin and Hortensin, the Flavonoids From Millingtonia Hortensis L. Environ Mol Mutagen. 1992;20(4):307-12. PubMed PMID: 1425610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. AU - Chulasiri,M, AU - Bunyapraphatsara,N, AU - Moongkarndi,P, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 307 EP - 12 JF - Environmental and molecular mutagenesis JO - Environ Mol Mutagen VL - 20 IS - 4 N2 - Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2-aminoanthracene, aflatoxin B1 (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively. SN - 0893-6692 UR - https://www.unboundmedicine.com/medline/citation/1425610/Mutagenicity_and_antimutagenicity_of_hispidulin_and_hortensin_the_flavonoids_from_Millingtonia_hortensis_L_ DB - PRIME DP - Unbound Medicine ER -