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Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected].
Eur J Immunol. 1992 Nov; 22(11):2929-35.EJ

Abstract

Using anti-murine interleukin-2 receptor beta chain (IL-2R beta) monoclonal antibody (mAb), we have examined the expression of IL-2R beta on murine thymocyte subpopulations. We found that it was constitutively expressed on 1%-4% of thymocytes in an almost mutually exclusive fashion with IL-2R alpha. The expression of IL-2R beta is developmentally regulated. While it is expressed mainly on T cell receptor gamma delta+ (TcR gamma delta+) cells during fetal age, the major subpopulation expressing IL-2R beta in adult mouse shifts to CD4-CD8-TcR alpha beta+ thymocytes. A considerable portion of CD4-CD8- TcR alpha beta+ cells in other organs, including spleen, bone marrow and liver, was also found to express IL-2R beta. In fetal thymus organ culture, the above thymocyte subset was induced to expand in response to exogeneous IL-2, and the expansion was inhibited by addition of anti-IL-2R beta mAb, suggesting that IL-2R beta is functional in this subpopulation. However, in vivo blockade of the IL-2/IL-2R pathway with the mAb did not exert any effects on the appearance of CD4-CD8- TcR alpha beta+ cells both in the thymus and the periphery. This indicates that the development of CD4-CD8- TcR alpha beta+ cells is not solely controlled by IL-2 but also by other complex elements.

Authors+Show Affiliations

Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1425918

Citation

Takeuchi, Y, et al. "Expression and Role of Interleukin-2 Receptor Beta Chain On CD4-CD8- T Cell Receptor Alpha Beta+ Cells [corrected]." European Journal of Immunology, vol. 22, no. 11, 1992, pp. 2929-35.
Takeuchi Y, Tanaka T, Hamamura K, et al. Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected]. Eur J Immunol. 1992;22(11):2929-35.
Takeuchi, Y., Tanaka, T., Hamamura, K., Sugimoto, T., Miyasaka, M., Yagita, H., & Okumura, K. (1992). Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected]. European Journal of Immunology, 22(11), 2929-35.
Takeuchi Y, et al. Expression and Role of Interleukin-2 Receptor Beta Chain On CD4-CD8- T Cell Receptor Alpha Beta+ Cells [corrected]. Eur J Immunol. 1992;22(11):2929-35. PubMed PMID: 1425918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected]. AU - Takeuchi,Y, AU - Tanaka,T, AU - Hamamura,K, AU - Sugimoto,T, AU - Miyasaka,M, AU - Yagita,H, AU - Okumura,K, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 2929 EP - 35 JF - European journal of immunology JO - Eur J Immunol VL - 22 IS - 11 N2 - Using anti-murine interleukin-2 receptor beta chain (IL-2R beta) monoclonal antibody (mAb), we have examined the expression of IL-2R beta on murine thymocyte subpopulations. We found that it was constitutively expressed on 1%-4% of thymocytes in an almost mutually exclusive fashion with IL-2R alpha. The expression of IL-2R beta is developmentally regulated. While it is expressed mainly on T cell receptor gamma delta+ (TcR gamma delta+) cells during fetal age, the major subpopulation expressing IL-2R beta in adult mouse shifts to CD4-CD8-TcR alpha beta+ thymocytes. A considerable portion of CD4-CD8- TcR alpha beta+ cells in other organs, including spleen, bone marrow and liver, was also found to express IL-2R beta. In fetal thymus organ culture, the above thymocyte subset was induced to expand in response to exogeneous IL-2, and the expansion was inhibited by addition of anti-IL-2R beta mAb, suggesting that IL-2R beta is functional in this subpopulation. However, in vivo blockade of the IL-2/IL-2R pathway with the mAb did not exert any effects on the appearance of CD4-CD8- TcR alpha beta+ cells both in the thymus and the periphery. This indicates that the development of CD4-CD8- TcR alpha beta+ cells is not solely controlled by IL-2 but also by other complex elements. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/1425918/Expression_and_role_of_interleukin_2_receptor_beta_chain_on_CD4_CD8__T_cell_receptor_alpha_beta+_cells_[corrected]_ DB - PRIME DP - Unbound Medicine ER -