Tags

Type your tag names separated by a space and hit enter

Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage.

Abstract

The histologic manifestations of rhodopsin-mediated versus short-wavelength classes of retinal phototoxicity were compared after spectral exposures of the albino rat retina. Animals were exposed to wave-bands of light centered at the peak of rhodopsin absorbance (green, 500 nm) or in the ultraviolet A (UVA; 360 nm). Intensity-damage curves generated for each wave-band indicated that UVA light was 50-80 times more effective than green light at causing photoreceptor cell losses. Examination of early ultrastructural changes in rod inner segments, outer segments, and retinal pigment epithelium revealed a remarkable degree of similarity between UVA and green light-induced damage. Furthermore, the two classes of damage were indistinguishable in terms of post-exposure recovery from threshold damage and regional distribution of photoreceptor cell loss along the vertical meridian. The finding of essentially identical histologic manifestations for the two classes of damage raises the possibility that they share a common biochemical etiology or pathway of cell destruction.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.

    Source

    MeSH

    Animals
    Differential Threshold
    Dose-Response Relationship, Radiation
    Female
    Light
    Photoreceptor Cells
    Pigment Epithelium of Eye
    Radiation Injuries, Experimental
    Rats
    Rats, Sprague-Dawley
    Retinal Diseases
    Rhodopsin
    Ultraviolet Rays

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    1428709

    Citation

    Rapp, L M., and S C. Smith. "Morphologic Comparisons Between Rhodopsin-mediated and Short-wavelength Classes of Retinal Light Damage." Investigative Ophthalmology & Visual Science, vol. 33, no. 12, 1992, pp. 3367-77.
    Rapp LM, Smith SC. Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage. Invest Ophthalmol Vis Sci. 1992;33(12):3367-77.
    Rapp, L. M., & Smith, S. C. (1992). Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage. Investigative Ophthalmology & Visual Science, 33(12), pp. 3367-77.
    Rapp LM, Smith SC. Morphologic Comparisons Between Rhodopsin-mediated and Short-wavelength Classes of Retinal Light Damage. Invest Ophthalmol Vis Sci. 1992;33(12):3367-77. PubMed PMID: 1428709.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage. AU - Rapp,L M, AU - Smith,S C, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 3367 EP - 77 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 33 IS - 12 N2 - The histologic manifestations of rhodopsin-mediated versus short-wavelength classes of retinal phototoxicity were compared after spectral exposures of the albino rat retina. Animals were exposed to wave-bands of light centered at the peak of rhodopsin absorbance (green, 500 nm) or in the ultraviolet A (UVA; 360 nm). Intensity-damage curves generated for each wave-band indicated that UVA light was 50-80 times more effective than green light at causing photoreceptor cell losses. Examination of early ultrastructural changes in rod inner segments, outer segments, and retinal pigment epithelium revealed a remarkable degree of similarity between UVA and green light-induced damage. Furthermore, the two classes of damage were indistinguishable in terms of post-exposure recovery from threshold damage and regional distribution of photoreceptor cell loss along the vertical meridian. The finding of essentially identical histologic manifestations for the two classes of damage raises the possibility that they share a common biochemical etiology or pathway of cell destruction. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/1428709/Morphologic_comparisons_between_rhodopsin_mediated_and_short_wavelength_classes_of_retinal_light_damage_ L2 - http://iovs.arvojournals.org/article.aspx?volume=33&page=3367 DB - PRIME DP - Unbound Medicine ER -