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Effect of enhanced erythropoiesis on iron absorption.
J Lab Clin Med. 1992 Nov; 120(5):746-51.JL

Abstract

To examine the influence of erythropoiesis on iron absorption, radioiron absorption tests were performed in normal subjects before and after a course of recombinant erythropoietin. The absorption of heme and nonheme iron from a standard meal was measured in nine subjects, and the absorption of a therapeutic dose of ferrous sulfate given with or without food was determined in an additional 11 subjects. The subcutaneous administration of 100 U recombinant human erythropoietin/kg body weight given on 10 successive days over a 2-week period induced a brisk increase in erythropoiesis and a sharp decrease in iron stores. With the standard meal, there was a modest increase in heme iron absorption from 47.0% to 58.6% (p < 0.05) and a dramatic five-fold rise in nonheme iron absorption from 5.9% to 31.8% (p < 0.001). The absorption of 50 mg iron as ferrous sulfate increased from 2.0% to 17.9% when given with food (p < 0.001) and from 7.0% to 24.6% when given with water (p < 0.001). To assess the effect of erythropoiesis independently of the induced changes in iron status, the absorption data were adjusted to a common serum ferritin level. The relative increase in iron absorption was still significant for both dietary nonheme iron (ratio 2.51, p < 0.02) and ferrous sulfate given with food (ratio 2.99, p < 0.01). It is concluded that the striking enhancement of iron absorption following regular erythropoietin administration in normal subjects is related to the combined effect of diminished iron stores and augmented erythropoiesis.

Authors+Show Affiliations

Department of Medicine, Kansas University Medical Center, Kansas City 66160-7402.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1431504

Citation

Skikne, B S., and J D. Cook. "Effect of Enhanced Erythropoiesis On Iron Absorption." The Journal of Laboratory and Clinical Medicine, vol. 120, no. 5, 1992, pp. 746-51.
Skikne BS, Cook JD. Effect of enhanced erythropoiesis on iron absorption. J Lab Clin Med. 1992;120(5):746-51.
Skikne, B. S., & Cook, J. D. (1992). Effect of enhanced erythropoiesis on iron absorption. The Journal of Laboratory and Clinical Medicine, 120(5), 746-51.
Skikne BS, Cook JD. Effect of Enhanced Erythropoiesis On Iron Absorption. J Lab Clin Med. 1992;120(5):746-51. PubMed PMID: 1431504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of enhanced erythropoiesis on iron absorption. AU - Skikne,B S, AU - Cook,J D, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 746 EP - 51 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 120 IS - 5 N2 - To examine the influence of erythropoiesis on iron absorption, radioiron absorption tests were performed in normal subjects before and after a course of recombinant erythropoietin. The absorption of heme and nonheme iron from a standard meal was measured in nine subjects, and the absorption of a therapeutic dose of ferrous sulfate given with or without food was determined in an additional 11 subjects. The subcutaneous administration of 100 U recombinant human erythropoietin/kg body weight given on 10 successive days over a 2-week period induced a brisk increase in erythropoiesis and a sharp decrease in iron stores. With the standard meal, there was a modest increase in heme iron absorption from 47.0% to 58.6% (p < 0.05) and a dramatic five-fold rise in nonheme iron absorption from 5.9% to 31.8% (p < 0.001). The absorption of 50 mg iron as ferrous sulfate increased from 2.0% to 17.9% when given with food (p < 0.001) and from 7.0% to 24.6% when given with water (p < 0.001). To assess the effect of erythropoiesis independently of the induced changes in iron status, the absorption data were adjusted to a common serum ferritin level. The relative increase in iron absorption was still significant for both dietary nonheme iron (ratio 2.51, p < 0.02) and ferrous sulfate given with food (ratio 2.99, p < 0.01). It is concluded that the striking enhancement of iron absorption following regular erythropoietin administration in normal subjects is related to the combined effect of diminished iron stores and augmented erythropoiesis. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/1431504/Effect_of_enhanced_erythropoiesis_on_iron_absorption_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -