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Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans.
J Lipid Res. 1992 Oct; 33(10):1493-501.JL

Abstract

Serum lipoprotein[a] (Lp[a]) is a strong risk factor for coronary heart disease. We therefore examined the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled experiments with healthy normocholesterolemic men and women. In Expt. I, 58 subjects consumed a control diet high in saturated fatty acids for 17 days. For the next 36 days, 6.5% of total energy intake from saturated fatty acids was replaced by monounsaturates plus polyunsaturates (monounsaturated fatty acid diet; n = 29) or by polyunsaturates alone (polyunsaturated fatty acid diet; n = 29). Both diets caused a slight, nonsignificant, increase in median Lp[a] levels, with no difference between diets. In Expt. II, 10% of energy from the cholesterol-raising saturated fatty acids (lauric, myristic, and palmitic acid) was replaced by oleic acid or by trans-monounsaturated fatty acids. Each of the 59 participants received each diet for 3 weeks in random order. The median level of Lp[a] was 26 mg/l on the saturated fatty acid diet; it increased to 32 mg/l (P less than 0.020) on the oleic acid diet and to 45 mg/l (P less than 0.001) on the trans-fatty acid diet. The difference in Lp[a] between the trans-fatty acid and the oleic acid diets was also highly significant (P less than 0.001). Expt. III involved 56 subjects; all received 8% of energy from stearic acid, from linoleic acid, or from trans-monounsaturates, for 3 weeks each. All other nutrients were equal.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Human Biology, Limburg University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1431574

Citation

Mensink, R P., et al. "Effect of Dietary Cis and Trans Fatty Acids On Serum Lipoprotein[a] Levels in Humans." Journal of Lipid Research, vol. 33, no. 10, 1992, pp. 1493-501.
Mensink RP, Zock PL, Katan MB, et al. Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. J Lipid Res. 1992;33(10):1493-501.
Mensink, R. P., Zock, P. L., Katan, M. B., & Hornstra, G. (1992). Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. Journal of Lipid Research, 33(10), 1493-501.
Mensink RP, et al. Effect of Dietary Cis and Trans Fatty Acids On Serum Lipoprotein[a] Levels in Humans. J Lipid Res. 1992;33(10):1493-501. PubMed PMID: 1431574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. AU - Mensink,R P, AU - Zock,P L, AU - Katan,M B, AU - Hornstra,G, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 1493 EP - 501 JF - Journal of lipid research JO - J. Lipid Res. VL - 33 IS - 10 N2 - Serum lipoprotein[a] (Lp[a]) is a strong risk factor for coronary heart disease. We therefore examined the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled experiments with healthy normocholesterolemic men and women. In Expt. I, 58 subjects consumed a control diet high in saturated fatty acids for 17 days. For the next 36 days, 6.5% of total energy intake from saturated fatty acids was replaced by monounsaturates plus polyunsaturates (monounsaturated fatty acid diet; n = 29) or by polyunsaturates alone (polyunsaturated fatty acid diet; n = 29). Both diets caused a slight, nonsignificant, increase in median Lp[a] levels, with no difference between diets. In Expt. II, 10% of energy from the cholesterol-raising saturated fatty acids (lauric, myristic, and palmitic acid) was replaced by oleic acid or by trans-monounsaturated fatty acids. Each of the 59 participants received each diet for 3 weeks in random order. The median level of Lp[a] was 26 mg/l on the saturated fatty acid diet; it increased to 32 mg/l (P less than 0.020) on the oleic acid diet and to 45 mg/l (P less than 0.001) on the trans-fatty acid diet. The difference in Lp[a] between the trans-fatty acid and the oleic acid diets was also highly significant (P less than 0.001). Expt. III involved 56 subjects; all received 8% of energy from stearic acid, from linoleic acid, or from trans-monounsaturates, for 3 weeks each. All other nutrients were equal.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/1431574/Effect_of_dietary_cis_and_trans_fatty_acids_on_serum_lipoprotein[a]_levels_in_humans_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=1431574 DB - PRIME DP - Unbound Medicine ER -