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Consequences of slow Wallerian degeneration for regenerating motor and sensory axons.
J Neurobiol. 1992 Jul; 23(5):521-36.JN

Abstract

The time course of Wallerian degeneration in the tibial and saphenous nerves was compared in Balb/c mice and mice of the C57BL/Ola strain (Lunn et al., 1989). Axons, particularly myelinated ones, in nerves of C57BL/Ola mice are very slow to degenerate, many still being present 3 weeks after axotomy. Nuclear numbers in the distal stump peak much later and do not reach the levels found in Balb/c mice; debris removal is very slow, and Schwann cell numbers only rise slightly above normal levels in the long term. Regeneration was investigated electrophysiologically and by electron microscopy (EM). Myelinated sensory axons regenerated slowly and incompletely compared with motor ones which were only slightly slowed after nerve crush (although they were significantly hindered after nerve section). Total myelinated axon numbers were still some 20% less than normal even after 200 days in sensory nerves. Even after all axons had degenerated in C57BL/Ola mice, regeneration rates of neither myelinated nor unmyelinated sensory axons reached those achieved in Balb/c mice. It is concluded that while regeneration can eventually proceed slowly when Wallerian degeneration is much delayed, the usual rapid time course of Wallerian degeneration is necessary if axons, particularly sensory ones, are to regenerate at optimal rates and to maximum extent. While local obstruction to axon growth probably impedes the early phase of regeneration in C57BL/Ola mice, it seems possible that a lack of adequate early signals affects regeneration permanently by minimizing the cell body reaction to injury.

Authors+Show Affiliations

University Laboratory of Physiology, Oxford, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1431835

Citation

Brown, M C., et al. "Consequences of Slow Wallerian Degeneration for Regenerating Motor and Sensory Axons." Journal of Neurobiology, vol. 23, no. 5, 1992, pp. 521-36.
Brown MC, Lunn ER, Perry VH. Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. J Neurobiol. 1992;23(5):521-36.
Brown, M. C., Lunn, E. R., & Perry, V. H. (1992). Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. Journal of Neurobiology, 23(5), 521-36.
Brown MC, Lunn ER, Perry VH. Consequences of Slow Wallerian Degeneration for Regenerating Motor and Sensory Axons. J Neurobiol. 1992;23(5):521-36. PubMed PMID: 1431835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. AU - Brown,M C, AU - Lunn,E R, AU - Perry,V H, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 521 EP - 36 JF - Journal of neurobiology JO - J Neurobiol VL - 23 IS - 5 N2 - The time course of Wallerian degeneration in the tibial and saphenous nerves was compared in Balb/c mice and mice of the C57BL/Ola strain (Lunn et al., 1989). Axons, particularly myelinated ones, in nerves of C57BL/Ola mice are very slow to degenerate, many still being present 3 weeks after axotomy. Nuclear numbers in the distal stump peak much later and do not reach the levels found in Balb/c mice; debris removal is very slow, and Schwann cell numbers only rise slightly above normal levels in the long term. Regeneration was investigated electrophysiologically and by electron microscopy (EM). Myelinated sensory axons regenerated slowly and incompletely compared with motor ones which were only slightly slowed after nerve crush (although they were significantly hindered after nerve section). Total myelinated axon numbers were still some 20% less than normal even after 200 days in sensory nerves. Even after all axons had degenerated in C57BL/Ola mice, regeneration rates of neither myelinated nor unmyelinated sensory axons reached those achieved in Balb/c mice. It is concluded that while regeneration can eventually proceed slowly when Wallerian degeneration is much delayed, the usual rapid time course of Wallerian degeneration is necessary if axons, particularly sensory ones, are to regenerate at optimal rates and to maximum extent. While local obstruction to axon growth probably impedes the early phase of regeneration in C57BL/Ola mice, it seems possible that a lack of adequate early signals affects regeneration permanently by minimizing the cell body reaction to injury. SN - 0022-3034 UR - https://www.unboundmedicine.com/medline/citation/1431835/Consequences_of_slow_Wallerian_degeneration_for_regenerating_motor_and_sensory_axons_ L2 - https://doi.org/10.1002/neu.480230507 DB - PRIME DP - Unbound Medicine ER -