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[The measurement of erythrocyte zinc protoporphyrin/heme ratio in various anemias in childhood].
Rinsho Ketsueki. 1992 Sep; 33(9):1199-203.RK

Abstract

The measurement of erythrocyte zinc protoporphyrin (ZPP) with a hematofluorometer is known to be a simple and cost-effective method to screen iron deficiency and lead poisoning. We measured ZPP on blood samples from 201 children suffering from various diseases, which revealed that ZPP has better sensitivity and specificity for identifying iron deficiency than serum ferritin and percent transferrin saturation. ZPP levels in various anemias were also measured. ZPP rose markedly (> 200 mumol/mol heme) in untreated iron deficiency anemia and returned to normal in 3-4 months since the initiation of iron therapy. Moderate elevation of ZPP was observed in acute leukemia (at onset and during induction therapy), MDS, aplastic anemia and some other anemic conditions. These findings suggest that erythrocyte ferrochelatase may be unexpectedly affected in anemias even except lead poisoning.

Authors+Show Affiliations

Kitajima H
Department of Pediatrics, Jikei University School of Medicine.
Kaneko T
No affiliation info available
Akatsuka J
No affiliation info available

MeSH

AnemiaAnemia, HypochromicChildChild, PreschoolErythrocytesHematologic DiseasesHemeHumansProtoporphyrins

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1433941

Citation

Kitajima, H, et al. "[The Measurement of Erythrocyte Zinc Protoporphyrin/heme Ratio in Various Anemias in Childhood]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 33, no. 9, 1992, pp. 1199-203.
Kitajima H, Kaneko T, Akatsuka J. [The measurement of erythrocyte zinc protoporphyrin/heme ratio in various anemias in childhood]. Rinsho Ketsueki. 1992;33(9):1199-203.
Kitajima, H., Kaneko, T., & Akatsuka, J. (1992). [The measurement of erythrocyte zinc protoporphyrin/heme ratio in various anemias in childhood]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 33(9), 1199-203.
Kitajima H, Kaneko T, Akatsuka J. [The Measurement of Erythrocyte Zinc Protoporphyrin/heme Ratio in Various Anemias in Childhood]. Rinsho Ketsueki. 1992;33(9):1199-203. PubMed PMID: 1433941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The measurement of erythrocyte zinc protoporphyrin/heme ratio in various anemias in childhood]. AU - Kitajima,H, AU - Kaneko,T, AU - Akatsuka,J, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 1199 EP - 203 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 33 IS - 9 N2 - The measurement of erythrocyte zinc protoporphyrin (ZPP) with a hematofluorometer is known to be a simple and cost-effective method to screen iron deficiency and lead poisoning. We measured ZPP on blood samples from 201 children suffering from various diseases, which revealed that ZPP has better sensitivity and specificity for identifying iron deficiency than serum ferritin and percent transferrin saturation. ZPP levels in various anemias were also measured. ZPP rose markedly (> 200 mumol/mol heme) in untreated iron deficiency anemia and returned to normal in 3-4 months since the initiation of iron therapy. Moderate elevation of ZPP was observed in acute leukemia (at onset and during induction therapy), MDS, aplastic anemia and some other anemic conditions. These findings suggest that erythrocyte ferrochelatase may be unexpectedly affected in anemias even except lead poisoning. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/1433941/[The_measurement_of_erythrocyte_zinc_protoporphyrin/heme_ratio_in_various_anemias_in_childhood]_ DB - PRIME DP - Unbound Medicine ER -