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[In vivo studies of residual allergen activity of hydrolysate feeding].
Monatsschr Kinderheilkd. 1992 Aug; 140(8):472-5.MK

Abstract

The capacity of food proteins to induce IgE-mediated reactions can be reduced by hydrolysis, heat treatment or ultrafiltration. It was the aim of our study to investigate the capacity of hydrolysates used for dietary purposes in cow's milk allergy to induce allergic symptoms in cow's milk sensitive children. Six different hydrolysates were tested by skin prick test and oral provocation test in 17 cow's milk sensitive children. Our data indicate that certain hydrolysates induce positive skin reactions as well as allergic symptoms after oral challenge. Casein hydrolysates were found to have the least residual allergenic activity. From our data we conclude that hydrolysates should be tested by titrated oral challenges before used in the diet of cow's milk sensitive children.

Authors+Show Affiliations

Rugo E
Universitäts-Kinderklinik, Klinikum Rudolf-Virchow, Berlin.
Wahn U
No affiliation info available

MeSH

AnaphylaxisChildChild, PreschoolFemaleFood HypersensitivityFood, FormulatedHumansImmunoglobulin EInfantInfant FoodIntradermal TestsMaleMilk HypersensitivityProtein Hydrolysates

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1435806

Citation

Rugo, E, and U Wahn. "[In Vivo Studies of Residual Allergen Activity of Hydrolysate Feeding]." Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, vol. 140, no. 8, 1992, pp. 472-5.
Rugo E, Wahn U. [In vivo studies of residual allergen activity of hydrolysate feeding]. Monatsschr Kinderheilkd. 1992;140(8):472-5.
Rugo, E., & Wahn, U. (1992). [In vivo studies of residual allergen activity of hydrolysate feeding]. Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, 140(8), 472-5.
Rugo E, Wahn U. [In Vivo Studies of Residual Allergen Activity of Hydrolysate Feeding]. Monatsschr Kinderheilkd. 1992;140(8):472-5. PubMed PMID: 1435806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [In vivo studies of residual allergen activity of hydrolysate feeding]. AU - Rugo,E, AU - Wahn,U, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 472 EP - 5 JF - Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde JO - Monatsschr Kinderheilkd VL - 140 IS - 8 N2 - The capacity of food proteins to induce IgE-mediated reactions can be reduced by hydrolysis, heat treatment or ultrafiltration. It was the aim of our study to investigate the capacity of hydrolysates used for dietary purposes in cow's milk allergy to induce allergic symptoms in cow's milk sensitive children. Six different hydrolysates were tested by skin prick test and oral provocation test in 17 cow's milk sensitive children. Our data indicate that certain hydrolysates induce positive skin reactions as well as allergic symptoms after oral challenge. Casein hydrolysates were found to have the least residual allergenic activity. From our data we conclude that hydrolysates should be tested by titrated oral challenges before used in the diet of cow's milk sensitive children. SN - 0026-9298 UR - https://www.unboundmedicine.com/medline/citation/1435806/[In_vivo_studies_of_residual_allergen_activity_of_hydrolysate_feeding]_ DB - PRIME DP - Unbound Medicine ER -