Tags

Type your tag names separated by a space and hit enter

Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study.
Pediatrics. 1992 Dec; 90(6):855-61.Ped

Abstract

The implications of low-level lead exposure for children's intellectual and academic performance at school age are uncertain. This issue was investigated in a prospective study of middle-class and upper-middle-class children with low lifetime exposures to lead. A battery of neuropsychological tests was administered at age 10 years to 148 children whose lead exposure and cognitive function had been previously assessed at ages 6, 12, 18, 24, and 57 months. Primary endpoints were Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Kaufman Test of Educational Achievement (K-TEA). Higher levels of blood lead at age 24 months, but not at other ages, were significantly associated with lower global scores on both the WISC-R and the K-TEA after adjustment for potential confounders. Over the range of approximately 0 to 25 micrograms/dL, a 0.48-mumol/L (10 micrograms/dL) increase in blood lead at 24 months was associated with a 5.8-point decline in WISC-R Full-Scale IQ (95% confidence interval: 1.7 to 9.9, P = .007) and an 8.9-point decline in K-TEA Battery Composite score (95% confidence interval: 4.2 to 13.6, P = .0003). Mean blood lead level at age 24 months was 0.31 mumol/L (6.5 micrograms/dL; SD: 4.9, 90% percentile: 12.5). Slightly elevated blood lead levels around the age of 24 months are associated with intellectual and academic performance deficits at age 10 years.

Authors+Show Affiliations

Department of Neurology, Children's Hospital, Boston, MA 02115.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1437425

Citation

Bellinger, D C., et al. "Low-level Lead Exposure, Intelligence and Academic Achievement: a Long-term Follow-up Study." Pediatrics, vol. 90, no. 6, 1992, pp. 855-61.
Bellinger DC, Stiles KM, Needleman HL. Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. Pediatrics. 1992;90(6):855-61.
Bellinger, D. C., Stiles, K. M., & Needleman, H. L. (1992). Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. Pediatrics, 90(6), 855-61.
Bellinger DC, Stiles KM, Needleman HL. Low-level Lead Exposure, Intelligence and Academic Achievement: a Long-term Follow-up Study. Pediatrics. 1992;90(6):855-61. PubMed PMID: 1437425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. AU - Bellinger,D C, AU - Stiles,K M, AU - Needleman,H L, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 855 EP - 61 JF - Pediatrics JO - Pediatrics VL - 90 IS - 6 N2 - The implications of low-level lead exposure for children's intellectual and academic performance at school age are uncertain. This issue was investigated in a prospective study of middle-class and upper-middle-class children with low lifetime exposures to lead. A battery of neuropsychological tests was administered at age 10 years to 148 children whose lead exposure and cognitive function had been previously assessed at ages 6, 12, 18, 24, and 57 months. Primary endpoints were Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Kaufman Test of Educational Achievement (K-TEA). Higher levels of blood lead at age 24 months, but not at other ages, were significantly associated with lower global scores on both the WISC-R and the K-TEA after adjustment for potential confounders. Over the range of approximately 0 to 25 micrograms/dL, a 0.48-mumol/L (10 micrograms/dL) increase in blood lead at 24 months was associated with a 5.8-point decline in WISC-R Full-Scale IQ (95% confidence interval: 1.7 to 9.9, P = .007) and an 8.9-point decline in K-TEA Battery Composite score (95% confidence interval: 4.2 to 13.6, P = .0003). Mean blood lead level at age 24 months was 0.31 mumol/L (6.5 micrograms/dL; SD: 4.9, 90% percentile: 12.5). Slightly elevated blood lead levels around the age of 24 months are associated with intellectual and academic performance deficits at age 10 years. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/1437425/Low_level_lead_exposure_intelligence_and_academic_achievement:_a_long_term_follow_up_study_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=1437425 DB - PRIME DP - Unbound Medicine ER -