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Clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis: a prospective double-blind clinical trial.
South Med J. 1992 Nov; 85(11):1077-80.SM

Abstract

Bacterial vaginosis is common among patients seen by gynecologists. Several types of therapy have been proposed. The purpose of this prospective, randomized, double-blind clinical trial was to examine the efficacy of clindamycin vaginal cream for the treatment of bacterial vaginosis. Sixty patients with symptoms of bacterial vaginosis were randomized into the study, and 46 completed the protocol. Twenty-three patients received 2% clindamycin vaginal cream (5 g applied intravaginally at bedtime for 7 days), with placebo oral tablets twice daily for 7 days. The other 23 patients received oral metronidazole tablets (500 mg twice a day for 7 days) and placebo vaginal cream (5 g intravaginally for 7 days). The cure rates for the two regimens were comparable. Twenty-two (97%) of the patients treated with clindamycin vaginal cream had improvement or cure at the first follow-up visit versus 19 (83%) of those taking metronidazole. There was no statistically significant difference between the two results. Side effects for both regimens were comparable. We conclude that 2% clindamycin vaginal cream offers similar efficacy and safety to standard oral metronidazole therapy for bacterial vaginosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University Medical Center of Jacksonville, FL 32209.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1439943

Citation

Andres, F J., et al. "Clindamycin Vaginal Cream Versus Oral Metronidazole in the Treatment of Bacterial Vaginosis: a Prospective Double-blind Clinical Trial." Southern Medical Journal, vol. 85, no. 11, 1992, pp. 1077-80.
Andres FJ, Parker R, Hosein I, et al. Clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis: a prospective double-blind clinical trial. South Med J. 1992;85(11):1077-80.
Andres, F. J., Parker, R., Hosein, I., & Benrubi, G. I. (1992). Clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis: a prospective double-blind clinical trial. Southern Medical Journal, 85(11), 1077-80.
Andres FJ, et al. Clindamycin Vaginal Cream Versus Oral Metronidazole in the Treatment of Bacterial Vaginosis: a Prospective Double-blind Clinical Trial. South Med J. 1992;85(11):1077-80. PubMed PMID: 1439943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis: a prospective double-blind clinical trial. AU - Andres,F J, AU - Parker,R, AU - Hosein,I, AU - Benrubi,G I, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1077 EP - 80 JF - Southern medical journal JO - South Med J VL - 85 IS - 11 N2 - Bacterial vaginosis is common among patients seen by gynecologists. Several types of therapy have been proposed. The purpose of this prospective, randomized, double-blind clinical trial was to examine the efficacy of clindamycin vaginal cream for the treatment of bacterial vaginosis. Sixty patients with symptoms of bacterial vaginosis were randomized into the study, and 46 completed the protocol. Twenty-three patients received 2% clindamycin vaginal cream (5 g applied intravaginally at bedtime for 7 days), with placebo oral tablets twice daily for 7 days. The other 23 patients received oral metronidazole tablets (500 mg twice a day for 7 days) and placebo vaginal cream (5 g intravaginally for 7 days). The cure rates for the two regimens were comparable. Twenty-two (97%) of the patients treated with clindamycin vaginal cream had improvement or cure at the first follow-up visit versus 19 (83%) of those taking metronidazole. There was no statistically significant difference between the two results. Side effects for both regimens were comparable. We conclude that 2% clindamycin vaginal cream offers similar efficacy and safety to standard oral metronidazole therapy for bacterial vaginosis. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/1439943/Clindamycin_vaginal_cream_versus_oral_metronidazole_in_the_treatment_of_bacterial_vaginosis:_a_prospective_double_blind_clinical_trial_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1439943.ui DB - PRIME DP - Unbound Medicine ER -