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Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study.

Abstract

OBJECTIVE

Our objective was to evaluate the risk for endometrial cancer in relation to reproductive, menstrual, and medical factors.

STUDY DESIGN

A case-control study of 405 endometrial cancer cases and 297 population controls in five areas of the United States enabled risk to be evaluated.

RESULTS

A major risk factor was the absence of a prior pregnancy (relative risk 2.8, 95% confidence interval 1.7 to 4.6). The protective effect of pregnancy appeared to reflect the influence of term births, because spontaneous and induced abortions were unrelated to risk. Among nulliparous women infertility was a significant risk factor, with women having sought medical advice having nearly eight times the risk of those without difficulty conceiving. After adjustment for other reproductive characteristics, age at first birth and duration of breast-feeding were not related to risk.

CONCLUSIONS

Elevated risks were found for subjects reporting early ages at menarche (relative risk 2.4 for ages < 12 vs > or = 15) and longer days of flow (relative risk 1.9 for > or = 7 vs < 4 days), but there was no relationship with late ages at natural menopause. Height was not associated with risk, but there was a significant relation to weight, with the risk for 200 versus < 125 pounds being 7.2 (95% confidence interval 3.9 to 13.3). After adjustment for weight and other factors, histories of hypertension and gallbladder disease were not significantly related to risk, but an effect of diabetes persisted (relative risk 2.0, 95% confidence interval 1.1 to 3.6). Hirsutism developing at older ages was also significantly related (relative risk 2.0, 95% confidence interval 1.2 to 3.4).

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  • Authors+Show Affiliations

    ,

    Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.

    , , , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Aged
    Case-Control Studies
    Diabetes Complications
    Female
    Hirsutism
    Humans
    Menarche
    Menstruation
    Middle Aged
    Obesity
    Pregnancy
    Reproduction
    Risk Factors
    United States
    Uterine Neoplasms

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    1442985

    Citation

    Brinton, L A., et al. "Reproductive, Menstrual, and Medical Risk Factors for Endometrial Cancer: Results From a Case-control Study." American Journal of Obstetrics and Gynecology, vol. 167, no. 5, 1992, pp. 1317-25.
    Brinton LA, Berman ML, Mortel R, et al. Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol. 1992;167(5):1317-25.
    Brinton, L. A., Berman, M. L., Mortel, R., Twiggs, L. B., Barrett, R. J., Wilbanks, G. D., ... Hoover, R. N. (1992). Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. American Journal of Obstetrics and Gynecology, 167(5), pp. 1317-25.
    Brinton LA, et al. Reproductive, Menstrual, and Medical Risk Factors for Endometrial Cancer: Results From a Case-control Study. Am J Obstet Gynecol. 1992;167(5):1317-25. PubMed PMID: 1442985.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. AU - Brinton,L A, AU - Berman,M L, AU - Mortel,R, AU - Twiggs,L B, AU - Barrett,R J, AU - Wilbanks,G D, AU - Lannom,L, AU - Hoover,R N, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1317 EP - 25 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 167 IS - 5 N2 - OBJECTIVE: Our objective was to evaluate the risk for endometrial cancer in relation to reproductive, menstrual, and medical factors. STUDY DESIGN: A case-control study of 405 endometrial cancer cases and 297 population controls in five areas of the United States enabled risk to be evaluated. RESULTS: A major risk factor was the absence of a prior pregnancy (relative risk 2.8, 95% confidence interval 1.7 to 4.6). The protective effect of pregnancy appeared to reflect the influence of term births, because spontaneous and induced abortions were unrelated to risk. Among nulliparous women infertility was a significant risk factor, with women having sought medical advice having nearly eight times the risk of those without difficulty conceiving. After adjustment for other reproductive characteristics, age at first birth and duration of breast-feeding were not related to risk. CONCLUSIONS: Elevated risks were found for subjects reporting early ages at menarche (relative risk 2.4 for ages < 12 vs > or = 15) and longer days of flow (relative risk 1.9 for > or = 7 vs < 4 days), but there was no relationship with late ages at natural menopause. Height was not associated with risk, but there was a significant relation to weight, with the risk for 200 versus < 125 pounds being 7.2 (95% confidence interval 3.9 to 13.3). After adjustment for weight and other factors, histories of hypertension and gallbladder disease were not significantly related to risk, but an effect of diabetes persisted (relative risk 2.0, 95% confidence interval 1.1 to 3.6). Hirsutism developing at older ages was also significantly related (relative risk 2.0, 95% confidence interval 1.2 to 3.4). SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/1442985/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(11)91709-8 DB - PRIME DP - Unbound Medicine ER -