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DNA ploidy, S-phase fraction and mitotic indices as prognostic predictors of female breast cancer.
Anticancer Res. 1992 Sep-Oct; 12(5):1533-8.AR

Abstract

DNA ploidy, S-phase fraction (SPF), mitotic index (MI), volume corrected mitotic index (M/V index) and standard prognostic factors were related to disease outcome in a series of 363 women with breast cancer followed-up for over 10 years in our clinic. DNA ploidy and SPF were significantly related to histological type, tumour grade and mitotic indices (p < 0.001). In univariate survival analysis, pN status (p < 0.0001), tumour diameter (p < 0.0001), MI (p = 0.001), M/V index (p = 0.0003) and SPF (p = 0.015) predicted survival. In pN(-) tumours. MI (p = 0.059) was related to survival. In pN(+) tumours, tumour diameter (p = 0.0004), M/V index (p = 0.023) and SPF (p = 0.045) predicted survival. In multivariate survival analysis, tumour diameter (p < 0.001). M/V index (p < 0.007), pN status (p = 0.014) and patient age (p = 0.09) were independently related to survival. In pN(-) tumours, tumour diameter independently predicted survival (p = 0.033). In pN(+) tumours, tumour diameter (p < 0.001), M/V index (p = 0.006) and the year of treatment (p = 0.08) were independent predictors. The results show that tumour diameter, pN status and proliferative activity of cancer cells are important prognostic factors in breast cancer. Of the proliferation indices, M/V index and SPF are equally powerful predictors, and the use of M/V index is advocated due to simplicity of the assessment.

Authors+Show Affiliations

Department of Pathology, University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1444217

Citation

Lipponen, P, et al. "DNA Ploidy, S-phase Fraction and Mitotic Indices as Prognostic Predictors of Female Breast Cancer." Anticancer Research, vol. 12, no. 5, 1992, pp. 1533-8.
Lipponen P, Papinaho S, Eskelinen M, et al. DNA ploidy, S-phase fraction and mitotic indices as prognostic predictors of female breast cancer. Anticancer Res. 1992;12(5):1533-8.
Lipponen, P., Papinaho, S., Eskelinen, M., Klemi, P. J., Aaltomaa, S., Kosma, V. M., Marin, S., & Syrjänen, K. (1992). DNA ploidy, S-phase fraction and mitotic indices as prognostic predictors of female breast cancer. Anticancer Research, 12(5), 1533-8.
Lipponen P, et al. DNA Ploidy, S-phase Fraction and Mitotic Indices as Prognostic Predictors of Female Breast Cancer. Anticancer Res. 1992 Sep-Oct;12(5):1533-8. PubMed PMID: 1444217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA ploidy, S-phase fraction and mitotic indices as prognostic predictors of female breast cancer. AU - Lipponen,P, AU - Papinaho,S, AU - Eskelinen,M, AU - Klemi,P J, AU - Aaltomaa,S, AU - Kosma,V M, AU - Marin,S, AU - Syrjänen,K, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 1533 EP - 8 JF - Anticancer research JO - Anticancer Res VL - 12 IS - 5 N2 - DNA ploidy, S-phase fraction (SPF), mitotic index (MI), volume corrected mitotic index (M/V index) and standard prognostic factors were related to disease outcome in a series of 363 women with breast cancer followed-up for over 10 years in our clinic. DNA ploidy and SPF were significantly related to histological type, tumour grade and mitotic indices (p < 0.001). In univariate survival analysis, pN status (p < 0.0001), tumour diameter (p < 0.0001), MI (p = 0.001), M/V index (p = 0.0003) and SPF (p = 0.015) predicted survival. In pN(-) tumours. MI (p = 0.059) was related to survival. In pN(+) tumours, tumour diameter (p = 0.0004), M/V index (p = 0.023) and SPF (p = 0.045) predicted survival. In multivariate survival analysis, tumour diameter (p < 0.001). M/V index (p < 0.007), pN status (p = 0.014) and patient age (p = 0.09) were independently related to survival. In pN(-) tumours, tumour diameter independently predicted survival (p = 0.033). In pN(+) tumours, tumour diameter (p < 0.001), M/V index (p = 0.006) and the year of treatment (p = 0.08) were independent predictors. The results show that tumour diameter, pN status and proliferative activity of cancer cells are important prognostic factors in breast cancer. Of the proliferation indices, M/V index and SPF are equally powerful predictors, and the use of M/V index is advocated due to simplicity of the assessment. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/1444217/DNA_ploidy_S_phase_fraction_and_mitotic_indices_as_prognostic_predictors_of_female_breast_cancer_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -