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Fine needle aspiration of pancreatic cystic epithelial neoplasms.
Acta Cytol. 1992 Nov-Dec; 36(6):881-6.AC

Abstract

Pancreatic cystic epithelial neoplasms present diagnostic challenges in cytology. An accurate diagnosis is important since the prognosis and treatment may vary. We report the cytologic features in fine needle aspirates of four cases of cystic neoplasms of the pancreas (two micro-cystic adenomas, one mucinous cystic neoplasm and one mucinous cystadenocarcinoma). Smears were evaluated as to their cellularity, content and predominant cell type. Aspirates from the microcystic adenomas yielded hypocellular material with rare strips of cuboidal cells having bland nuclei and pale cytoplasm. No mucinous material was identified in the background, but the cells stained positively with periodic acid-Schiff stain. Smears from the mucinous cystic neoplasm were moderately cellular and contained abundant mucinous material. The columnar epithelial cells were arranged in tight sheets, clusters and strips. Most cells had benign nuclear features with focal mild nuclear atypia. Key cytologic findings noted in the mucinous cystadenocarcinoma were moderate cellularity, loose clusters of cells, single cells, overt malignant nuclear features and occasional signet ring cells. Pancreatic pseudocysts can be distinguished from pancreatic cystic epithelial neoplasms by the predominance of histiocytes and inflammatory cells and absence or paucity of epithelial cells. To differentiate microcystic adenomas from mucinous cystic neoplasms, the above criteria coupled with periodic acid-Schiff and mucin staining should effectively differentiate these diagnostic entities.

Authors+Show Affiliations

Department of Pathology, Baylor College of Medicine, Houston, Texas 77030.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1449026

Citation

Laucirica, R, et al. "Fine Needle Aspiration of Pancreatic Cystic Epithelial Neoplasms." Acta Cytologica, vol. 36, no. 6, 1992, pp. 881-6.
Laucirica R, Schwartz MR, Ramzy I. Fine needle aspiration of pancreatic cystic epithelial neoplasms. Acta Cytol. 1992;36(6):881-6.
Laucirica, R., Schwartz, M. R., & Ramzy, I. (1992). Fine needle aspiration of pancreatic cystic epithelial neoplasms. Acta Cytologica, 36(6), 881-6.
Laucirica R, Schwartz MR, Ramzy I. Fine Needle Aspiration of Pancreatic Cystic Epithelial Neoplasms. Acta Cytol. 1992 Nov-Dec;36(6):881-6. PubMed PMID: 1449026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine needle aspiration of pancreatic cystic epithelial neoplasms. AU - Laucirica,R, AU - Schwartz,M R, AU - Ramzy,I, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 881 EP - 6 JF - Acta cytologica JO - Acta Cytol VL - 36 IS - 6 N2 - Pancreatic cystic epithelial neoplasms present diagnostic challenges in cytology. An accurate diagnosis is important since the prognosis and treatment may vary. We report the cytologic features in fine needle aspirates of four cases of cystic neoplasms of the pancreas (two micro-cystic adenomas, one mucinous cystic neoplasm and one mucinous cystadenocarcinoma). Smears were evaluated as to their cellularity, content and predominant cell type. Aspirates from the microcystic adenomas yielded hypocellular material with rare strips of cuboidal cells having bland nuclei and pale cytoplasm. No mucinous material was identified in the background, but the cells stained positively with periodic acid-Schiff stain. Smears from the mucinous cystic neoplasm were moderately cellular and contained abundant mucinous material. The columnar epithelial cells were arranged in tight sheets, clusters and strips. Most cells had benign nuclear features with focal mild nuclear atypia. Key cytologic findings noted in the mucinous cystadenocarcinoma were moderate cellularity, loose clusters of cells, single cells, overt malignant nuclear features and occasional signet ring cells. Pancreatic pseudocysts can be distinguished from pancreatic cystic epithelial neoplasms by the predominance of histiocytes and inflammatory cells and absence or paucity of epithelial cells. To differentiate microcystic adenomas from mucinous cystic neoplasms, the above criteria coupled with periodic acid-Schiff and mucin staining should effectively differentiate these diagnostic entities. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/1449026/Fine_needle_aspiration_of_pancreatic_cystic_epithelial_neoplasms_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -
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