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Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration.
Am J Clin Pathol. 2003 Sep; 120(3):398-404.AJ

Abstract

All clinically and ultrasonographically suspected examples of intraductal papillary-mucinous neoplasm (IPMN) aspirated during a 17-month period were reviewed and analyzed for follow-up. We identified 18 cases of suspected IPMN in patients 52 to 87 years old. All patients had dilated pancreatic ducts, with 3 showing sonographically apparent intraductal papillary lesions; 5 had adjacent cystic or solid pancreatic masses. Cytologic preparations showed thick, glistening, viscid, abnormal mucus in all cases. Aspirates from 13 lesions (72%) were acellular or sparsely cellular, but entrapped single or loosely cohesive neoplastic cells were identified in 16 cases (89%). Goblet cell morphologic features were common (6/18 [33%]), but papillary clusters and dysplastic changes were infrequent (3 [17%] each). In keeping with current therapeutic thinking, confirmatory histologic follow-up was available for only 4 patients (22%), as most people with lesions clinically, sonographically, and cytologically consistent with IPMN are elderly and often have comorbid conditions. Although endoscopic ultrasound-guided fine-needle aspiration has important limitations, gross and cytologic findings can aid in confirming the suspected diagnosis, and integration of complete clinical, sonographic, and cytologic information may be the best way to reach the most accurate diagnosis possible.

Authors+Show Affiliations

Departments of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14502804

Citation

Stelow, Edward B., et al. "Intraductal Papillary-mucinous Neoplasm of the Pancreas. the Findings and Limitations of Cytologic Samples Obtained By Endoscopic Ultrasound-guided Fine-needle Aspiration." American Journal of Clinical Pathology, vol. 120, no. 3, 2003, pp. 398-404.
Stelow EB, Stanley MW, Bardales RH, et al. Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. Am J Clin Pathol. 2003;120(3):398-404.
Stelow, E. B., Stanley, M. W., Bardales, R. H., Mallery, S., Lai, R., Linzie, B. M., & Pambuccian, S. E. (2003). Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. American Journal of Clinical Pathology, 120(3), 398-404.
Stelow EB, et al. Intraductal Papillary-mucinous Neoplasm of the Pancreas. the Findings and Limitations of Cytologic Samples Obtained By Endoscopic Ultrasound-guided Fine-needle Aspiration. Am J Clin Pathol. 2003;120(3):398-404. PubMed PMID: 14502804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. AU - Stelow,Edward B, AU - Stanley,Michael W, AU - Bardales,Ricardo H, AU - Mallery,Shawn, AU - Lai,Rebecca, AU - Linzie,Bradley M, AU - Pambuccian,Stefan E, PY - 2003/9/25/pubmed PY - 2003/10/4/medline PY - 2003/9/25/entrez SP - 398 EP - 404 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 120 IS - 3 N2 - All clinically and ultrasonographically suspected examples of intraductal papillary-mucinous neoplasm (IPMN) aspirated during a 17-month period were reviewed and analyzed for follow-up. We identified 18 cases of suspected IPMN in patients 52 to 87 years old. All patients had dilated pancreatic ducts, with 3 showing sonographically apparent intraductal papillary lesions; 5 had adjacent cystic or solid pancreatic masses. Cytologic preparations showed thick, glistening, viscid, abnormal mucus in all cases. Aspirates from 13 lesions (72%) were acellular or sparsely cellular, but entrapped single or loosely cohesive neoplastic cells were identified in 16 cases (89%). Goblet cell morphologic features were common (6/18 [33%]), but papillary clusters and dysplastic changes were infrequent (3 [17%] each). In keeping with current therapeutic thinking, confirmatory histologic follow-up was available for only 4 patients (22%), as most people with lesions clinically, sonographically, and cytologically consistent with IPMN are elderly and often have comorbid conditions. Although endoscopic ultrasound-guided fine-needle aspiration has important limitations, gross and cytologic findings can aid in confirming the suspected diagnosis, and integration of complete clinical, sonographic, and cytologic information may be the best way to reach the most accurate diagnosis possible. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/14502804/Intraductal_papillary_mucinous_neoplasm_of_the_pancreas__The_findings_and_limitations_of_cytologic_samples_obtained_by_endoscopic_ultrasound_guided_fine_needle_aspiration_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/CEPK-542W-3885-2LP8 DB - PRIME DP - Unbound Medicine ER -