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The risk of dementia in relation to statins and other lipid lowering agents.
Neurol Res 2003; 25(6):601-4NR

Abstract

Recent epidemiological reports suggest that statins, and possibly other lipid lowering agents, might be protective for Alzheimer disease, and for other types of dementia. Importantly, however, epidemiological reports of this type are susceptible to indication bias, i.e. people who elect to take lipid-lowering agents might be healthier than those who do not, so that it may be these other health factors which explain their lower risk of dementia. Limited clinical trials data support the notion that statins, in particular, have important effects on cerebral cholesterol metabolism, but the link to clinical effects in dementia has yet to be established, and the mechanisms by which lipid lowering agents might confer protective effects is unclear. Dedicated clinical trials are now under way, and their results are awaited with great interest.

Authors+Show Affiliations

Divisions of Geriatric Medicine & Neurology, Dalhousie University, Halifax, Canada. Kenneth.Rockwood@dal.caNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

14503013

Citation

Rockwood, Kenneth, and Sultan Darvesh. "The Risk of Dementia in Relation to Statins and Other Lipid Lowering Agents." Neurological Research, vol. 25, no. 6, 2003, pp. 601-4.
Rockwood K, Darvesh S. The risk of dementia in relation to statins and other lipid lowering agents. Neurol Res. 2003;25(6):601-4.
Rockwood, K., & Darvesh, S. (2003). The risk of dementia in relation to statins and other lipid lowering agents. Neurological Research, 25(6), pp. 601-4.
Rockwood K, Darvesh S. The Risk of Dementia in Relation to Statins and Other Lipid Lowering Agents. Neurol Res. 2003;25(6):601-4. PubMed PMID: 14503013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risk of dementia in relation to statins and other lipid lowering agents. AU - Rockwood,Kenneth, AU - Darvesh,Sultan, PY - 2003/9/25/pubmed PY - 2003/12/5/medline PY - 2003/9/25/entrez SP - 601 EP - 4 JF - Neurological research JO - Neurol. Res. VL - 25 IS - 6 N2 - Recent epidemiological reports suggest that statins, and possibly other lipid lowering agents, might be protective for Alzheimer disease, and for other types of dementia. Importantly, however, epidemiological reports of this type are susceptible to indication bias, i.e. people who elect to take lipid-lowering agents might be healthier than those who do not, so that it may be these other health factors which explain their lower risk of dementia. Limited clinical trials data support the notion that statins, in particular, have important effects on cerebral cholesterol metabolism, but the link to clinical effects in dementia has yet to be established, and the mechanisms by which lipid lowering agents might confer protective effects is unclear. Dedicated clinical trials are now under way, and their results are awaited with great interest. SN - 0161-6412 UR - https://www.unboundmedicine.com/medline/citation/14503013/The_risk_of_dementia_in_relation_to_statins_and_other_lipid_lowering_agents_ L2 - http://www.tandfonline.com/doi/full/10.1179/016164103101202039 DB - PRIME DP - Unbound Medicine ER -