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Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study.
Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):853-9.CE

Abstract

Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues. Several common polymorphisms of the ER-alpha gene have been reported to be associated with alterations in receptor expression and function. We evaluated the hypothesis that genetic polymorphisms in the ER-alpha gene may be associated with breast cancer risk in a population-based case-control study conducted in urban Shanghai during 1996-1998. Two RFLPs at the ER-alpha gene locus, denoted as PvuII and XbaI, were examined in 1069 breast cancer cases and 1166 age frequency-matched controls. PvuII polymorphism was associated with an increased risk of breast cancer with the age-adjusted odds ratios for genotypes Pp and pp being 1.3 [95% confidence interval (CI), 1.0-1.7) and 1.4 (95% CI, 1.1-1.8), respectively, comparing to genotype PP. The XbaI polymorphism was associated with a nonsignificantly elevated risk. The odds ratios for genotypes Xx and xx were 1.2 (95% CI, 0.7-1.9) and 1.3 (95% CI, 0.8-2.0), respectively, and the elevated risks were mainly confined to older or postmenopausal women. No apparent synergetic effect of these two polymorphisms was identified. Results of this study indicate that genetic polymorphisms in the ER-alpha gene may play a role in the etiology of breast cancer.

Authors+Show Affiliations

Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA. qiuyin.cai@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14504194

Citation

Cai, Qiuyin, et al. "Genetic Polymorphisms in the Estrogen Receptor Alpha Gene and Risk of Breast Cancer: Results From the Shanghai Breast Cancer Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 9, 2003, pp. 853-9.
Cai Q, Shu XO, Jin F, et al. Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):853-9.
Cai, Q., Shu, X. O., Jin, F., Dai, Q., Wen, W., Cheng, J. R., Gao, Y. T., & Zheng, W. (2003). Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(9), 853-9.
Cai Q, et al. Genetic Polymorphisms in the Estrogen Receptor Alpha Gene and Risk of Breast Cancer: Results From the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):853-9. PubMed PMID: 14504194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study. AU - Cai,Qiuyin, AU - Shu,Xiao-Ou, AU - Jin,Fan, AU - Dai,Qi, AU - Wen,Wanqing, AU - Cheng,Jia-Rong, AU - Gao,Yu-Tang, AU - Zheng,Wei, PY - 2003/9/25/pubmed PY - 2003/12/13/medline PY - 2003/9/25/entrez SP - 853 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 12 IS - 9 N2 - Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues. Several common polymorphisms of the ER-alpha gene have been reported to be associated with alterations in receptor expression and function. We evaluated the hypothesis that genetic polymorphisms in the ER-alpha gene may be associated with breast cancer risk in a population-based case-control study conducted in urban Shanghai during 1996-1998. Two RFLPs at the ER-alpha gene locus, denoted as PvuII and XbaI, were examined in 1069 breast cancer cases and 1166 age frequency-matched controls. PvuII polymorphism was associated with an increased risk of breast cancer with the age-adjusted odds ratios for genotypes Pp and pp being 1.3 [95% confidence interval (CI), 1.0-1.7) and 1.4 (95% CI, 1.1-1.8), respectively, comparing to genotype PP. The XbaI polymorphism was associated with a nonsignificantly elevated risk. The odds ratios for genotypes Xx and xx were 1.2 (95% CI, 0.7-1.9) and 1.3 (95% CI, 0.8-2.0), respectively, and the elevated risks were mainly confined to older or postmenopausal women. No apparent synergetic effect of these two polymorphisms was identified. Results of this study indicate that genetic polymorphisms in the ER-alpha gene may play a role in the etiology of breast cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14504194/Genetic_polymorphisms_in_the_estrogen_receptor_alpha_gene_and_risk_of_breast_cancer:_results_from_the_Shanghai_Breast_Cancer_Study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14504194 DB - PRIME DP - Unbound Medicine ER -