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Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study.

Abstract

Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged 55-69 years at entry. In September 1986, the cohort members completed a questionnaire on risk factors for cancer and provided toenail clippings for determination of baseline selenium status. After 6.3 years of follow-up, 540 incident prostate carcinoma cases and 1,211 subcohort members with complete toenail selenium data were available for case-cohort analyses. In multivariate survival analysis, an inverse association between toenail selenium level and prostate cancer risk was observed. Incidence rate ratios in increasing selenium quintiles were 1.00 (ref), 1.05, 0.69, 0.75, and 0.69 (95% confidence interval, 0.48-0.99), respectively (P-trend=0.008). This association persisted after exclusion of cases diagnosed during early follow-up. The inverse association was more pronounced in ex-smokers than current smokers, and unclear in never-smokers. Analysis of effect modification by intake of antioxidant vitamins C, E, and the carotenoids alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, and lutein/zeaxanthin showed a strong, significant interaction with beta-cryptoxanthin, and to a lesser extent with vitamin C. These results confirm the hypothesis that higher selenium intake may reduce prostate cancer risk. Future research on optimum dose level is needed.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, 6200 MD Maastricht, The Netherlands. pa.vandenbrandt@epid.unimaas.ntNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14504196

Citation

van den Brandt, Piet A., et al. "Toenail Selenium Levels and the Subsequent Risk of Prostate Cancer: a Prospective Cohort Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 9, 2003, pp. 866-71.
van den Brandt PA, Zeegers MP, Bode P, et al. Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):866-71.
van den Brandt, P. A., Zeegers, M. P., Bode, P., & Goldbohm, R. A. (2003). Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(9), pp. 866-71.
van den Brandt PA, et al. Toenail Selenium Levels and the Subsequent Risk of Prostate Cancer: a Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):866-71. PubMed PMID: 14504196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. AU - van den Brandt,Piet A, AU - Zeegers,Maurice P A, AU - Bode,Peter, AU - Goldbohm,R Alexandra, PY - 2003/9/25/pubmed PY - 2003/12/13/medline PY - 2003/9/25/entrez SP - 866 EP - 71 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 9 N2 - Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged 55-69 years at entry. In September 1986, the cohort members completed a questionnaire on risk factors for cancer and provided toenail clippings for determination of baseline selenium status. After 6.3 years of follow-up, 540 incident prostate carcinoma cases and 1,211 subcohort members with complete toenail selenium data were available for case-cohort analyses. In multivariate survival analysis, an inverse association between toenail selenium level and prostate cancer risk was observed. Incidence rate ratios in increasing selenium quintiles were 1.00 (ref), 1.05, 0.69, 0.75, and 0.69 (95% confidence interval, 0.48-0.99), respectively (P-trend=0.008). This association persisted after exclusion of cases diagnosed during early follow-up. The inverse association was more pronounced in ex-smokers than current smokers, and unclear in never-smokers. Analysis of effect modification by intake of antioxidant vitamins C, E, and the carotenoids alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, and lutein/zeaxanthin showed a strong, significant interaction with beta-cryptoxanthin, and to a lesser extent with vitamin C. These results confirm the hypothesis that higher selenium intake may reduce prostate cancer risk. Future research on optimum dose level is needed. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14504196/Toenail_selenium_levels_and_the_subsequent_risk_of_prostate_cancer:_a_prospective_cohort_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14504196 DB - PRIME DP - Unbound Medicine ER -