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Dietary intake of heterocyclic amines and cancers of the esophagus and gastric cardia.
Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):940-4.CE

Abstract

The results of two epidemiological studies suggest that high intake of heterocyclic amines, which are formed on the surface of meats cooked at high temperatures, might be associated with increased risk of esophageal or cardia cancers. Our aim was to further investigate heterocyclic amine intake and risk of these cancers. We examined data from a nationwide, population-based, case-control study of risk factors for adenocarcinoma of the esophagus and gastric cardia and squamous cell carcinoma of the esophagus in Sweden, with 185, 258, and 165 cases, respectively, and 815 controls. Heterocyclic amine intake was estimated based on the frequency of consumption and degree of surface browning of commonly fried meats, and the consumption of pan juices. Statistically nonsignificant 50-70% higher risks of esophageal squamous cell carcinoma were observed among individuals in the highest quartile levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, and 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine relative to those in the lowest. Dose-risk trends were evident. Subjects reporting high intake of all three heterocyclic amines had an odds ratio of 2.4 (95% confidence interval, 1.2-4.8) relative to those with low intake of all three substances. In contrast, no association was found with risk of adenocarcinoma of the esophagus or gastric cardia. Heterocyclic amine intake might be associated with an increase in risk of squamous cell carcinoma of the esophagus. Given the dearth of epidemiological data regarding these cancers and the lack of established biological mechanisms, confirmatory data are needed.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden. terry2@niehs.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14504209

Citation

Terry, Paul D., et al. "Dietary Intake of Heterocyclic Amines and Cancers of the Esophagus and Gastric Cardia." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 9, 2003, pp. 940-4.
Terry PD, Lagergren J, Wolk A, et al. Dietary intake of heterocyclic amines and cancers of the esophagus and gastric cardia. Cancer Epidemiol Biomarkers Prev. 2003;12(9):940-4.
Terry, P. D., Lagergren, J., Wolk, A., Steineck, G., & Nyrén, O. (2003). Dietary intake of heterocyclic amines and cancers of the esophagus and gastric cardia. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(9), 940-4.
Terry PD, et al. Dietary Intake of Heterocyclic Amines and Cancers of the Esophagus and Gastric Cardia. Cancer Epidemiol Biomarkers Prev. 2003;12(9):940-4. PubMed PMID: 14504209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of heterocyclic amines and cancers of the esophagus and gastric cardia. AU - Terry,Paul D, AU - Lagergren,Jesper, AU - Wolk,Alicja, AU - Steineck,Gunnar, AU - Nyrén,Olof, PY - 2003/9/25/pubmed PY - 2003/12/13/medline PY - 2003/9/25/entrez SP - 940 EP - 4 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 12 IS - 9 N2 - The results of two epidemiological studies suggest that high intake of heterocyclic amines, which are formed on the surface of meats cooked at high temperatures, might be associated with increased risk of esophageal or cardia cancers. Our aim was to further investigate heterocyclic amine intake and risk of these cancers. We examined data from a nationwide, population-based, case-control study of risk factors for adenocarcinoma of the esophagus and gastric cardia and squamous cell carcinoma of the esophagus in Sweden, with 185, 258, and 165 cases, respectively, and 815 controls. Heterocyclic amine intake was estimated based on the frequency of consumption and degree of surface browning of commonly fried meats, and the consumption of pan juices. Statistically nonsignificant 50-70% higher risks of esophageal squamous cell carcinoma were observed among individuals in the highest quartile levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, and 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine relative to those in the lowest. Dose-risk trends were evident. Subjects reporting high intake of all three heterocyclic amines had an odds ratio of 2.4 (95% confidence interval, 1.2-4.8) relative to those with low intake of all three substances. In contrast, no association was found with risk of adenocarcinoma of the esophagus or gastric cardia. Heterocyclic amine intake might be associated with an increase in risk of squamous cell carcinoma of the esophagus. Given the dearth of epidemiological data regarding these cancers and the lack of established biological mechanisms, confirmatory data are needed. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14504209/Dietary_intake_of_heterocyclic_amines_and_cancers_of_the_esophagus_and_gastric_cardia_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14504209 DB - PRIME DP - Unbound Medicine ER -