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Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis.
J Gastroenterol. 2003; 38(8):791-5.JG

Abstract

A 64-year-old man, who came to us with diarrhea, presented with ectodermal changes such as hyperpigmentation, alopecia, and onychatrophy, and was affected by polyposis in the colorectum and stomach. The polyps were histologically consistent with those in Cronkhite-Canada syndrome (CCS). Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. Treatment with prednisolone ameliorated the symptoms and the gastrointestinal polyposis, while the cancer was successfully treated with a hemicolectomy. Six months after the surgery, the patient developed nephropathy, with nephrotic-range proteinuria, without recurrence of the cancer. The biopsied renal specimen showed membranous glomerulonephritis. This is a rare case of CCS associated with various complications such as colon cancer, portal vein thrombosis, a high titer of antinuclear antibodies, and membranous glomerulonephritis. Although the pathogenesis of CCS is essentially unknown, these complications might have been indicative of an underlying immunological abnormality.

Authors+Show Affiliations

Department of Internal Medicine, Division of Gastroenterology, Belland General Hospital, Sakai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

14505136

Citation

Takeuchi, Yoji, et al. "Cronkhite-Canada Syndrome With Colon Cancer, Portal Thrombosis, High Titer of Antinuclear Antibodies, and Membranous Glomerulonephritis." Journal of Gastroenterology, vol. 38, no. 8, 2003, pp. 791-5.
Takeuchi Y, Yoshikawa M, Tsukamoto N, et al. Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. J Gastroenterol. 2003;38(8):791-5.
Takeuchi, Y., Yoshikawa, M., Tsukamoto, N., Shiroi, A., Hoshida, Y., Enomoto, Y., Kimura, T., Yamamoto, K., Shiiki, H., Kikuchi, E., & Fukui, H. (2003). Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. Journal of Gastroenterology, 38(8), 791-5.
Takeuchi Y, et al. Cronkhite-Canada Syndrome With Colon Cancer, Portal Thrombosis, High Titer of Antinuclear Antibodies, and Membranous Glomerulonephritis. J Gastroenterol. 2003;38(8):791-5. PubMed PMID: 14505136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. AU - Takeuchi,Yoji, AU - Yoshikawa,Masahide, AU - Tsukamoto,Noboru, AU - Shiroi,Akira, AU - Hoshida,Yoshihiko, AU - Enomoto,Yasuhiro, AU - Kimura,Toshiaki, AU - Yamamoto,Kazuo, AU - Shiiki,Hideo, AU - Kikuchi,Eiryo, AU - Fukui,Hiroshi, PY - 2002/03/18/received PY - 2002/09/06/accepted PY - 2003/9/25/pubmed PY - 2004/2/11/medline PY - 2003/9/25/entrez SP - 791 EP - 5 JF - Journal of gastroenterology JO - J. Gastroenterol. VL - 38 IS - 8 N2 - A 64-year-old man, who came to us with diarrhea, presented with ectodermal changes such as hyperpigmentation, alopecia, and onychatrophy, and was affected by polyposis in the colorectum and stomach. The polyps were histologically consistent with those in Cronkhite-Canada syndrome (CCS). Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. Treatment with prednisolone ameliorated the symptoms and the gastrointestinal polyposis, while the cancer was successfully treated with a hemicolectomy. Six months after the surgery, the patient developed nephropathy, with nephrotic-range proteinuria, without recurrence of the cancer. The biopsied renal specimen showed membranous glomerulonephritis. This is a rare case of CCS associated with various complications such as colon cancer, portal vein thrombosis, a high titer of antinuclear antibodies, and membranous glomerulonephritis. Although the pathogenesis of CCS is essentially unknown, these complications might have been indicative of an underlying immunological abnormality. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/14505136/Cronkhite_Canada_syndrome_with_colon_cancer_portal_thrombosis_high_titer_of_antinuclear_antibodies_and_membranous_glomerulonephritis_ L2 - https://dx.doi.org/10.1007/s00535-002-1148-6 DB - PRIME DP - Unbound Medicine ER -