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Role of monocytes in atherogenesis.
Physiol Rev. 2003 Oct; 83(4):1069-112.PR

Abstract

This review focuses on the role of monocytes in the early phase of atherogenesis, before foam cell formation. An emerging consensus underscores the importance of the cellular inflammatory system in atherogenesis. Initiation of the process apparently hinges on accumulating low-density lipoproteins (LDL) undergoing oxidation and glycation, providing stimuli for the release of monocyte attracting chemokines and for the upregulation of endothelial adhesive molecules. These conditions favor monocyte transmigration to the intima, where chemically modified, aggregated, or proteoglycan- or antibody-complexed LDL may be endocytotically internalized via scavenger receptors present on the emergent macrophage surface. The differentiating monocytes in concert with T lymphocytes exert a modulating effect on lipoproteins. These events propagate a series of reactions entailing generation of lipid peroxides and expression of chemokines, adhesion molecules, cytokines, and growth factors, thereby sustaining an ongoing inflammatory process leading ultimately to lesion formation. New data emerging from studies using transgenic animals, notably mice, have provided novel insights into many of the cellular interactions and signaling mechanisms involving monocytes/macrophages in the atherogenic processes. A number of these studies, focusing on mechanisms for monocyte activation and the roles of adhesive molecules, chemokines, cytokines and growth factors, are addressed in this review.

Authors+Show Affiliations

Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway. Bjarne.Osterud@fagmed.uit.noNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14506301

Citation

Osterud, Bjarne, and Eirik Bjorklid. "Role of Monocytes in Atherogenesis." Physiological Reviews, vol. 83, no. 4, 2003, pp. 1069-112.
Osterud B, Bjorklid E. Role of monocytes in atherogenesis. Physiol Rev. 2003;83(4):1069-112.
Osterud, B., & Bjorklid, E. (2003). Role of monocytes in atherogenesis. Physiological Reviews, 83(4), 1069-112.
Osterud B, Bjorklid E. Role of Monocytes in Atherogenesis. Physiol Rev. 2003;83(4):1069-112. PubMed PMID: 14506301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of monocytes in atherogenesis. AU - Osterud,Bjarne, AU - Bjorklid,Eirik, PY - 2003/9/25/pubmed PY - 2003/11/13/medline PY - 2003/9/25/entrez SP - 1069 EP - 112 JF - Physiological reviews JO - Physiol. Rev. VL - 83 IS - 4 N2 - This review focuses on the role of monocytes in the early phase of atherogenesis, before foam cell formation. An emerging consensus underscores the importance of the cellular inflammatory system in atherogenesis. Initiation of the process apparently hinges on accumulating low-density lipoproteins (LDL) undergoing oxidation and glycation, providing stimuli for the release of monocyte attracting chemokines and for the upregulation of endothelial adhesive molecules. These conditions favor monocyte transmigration to the intima, where chemically modified, aggregated, or proteoglycan- or antibody-complexed LDL may be endocytotically internalized via scavenger receptors present on the emergent macrophage surface. The differentiating monocytes in concert with T lymphocytes exert a modulating effect on lipoproteins. These events propagate a series of reactions entailing generation of lipid peroxides and expression of chemokines, adhesion molecules, cytokines, and growth factors, thereby sustaining an ongoing inflammatory process leading ultimately to lesion formation. New data emerging from studies using transgenic animals, notably mice, have provided novel insights into many of the cellular interactions and signaling mechanisms involving monocytes/macrophages in the atherogenic processes. A number of these studies, focusing on mechanisms for monocyte activation and the roles of adhesive molecules, chemokines, cytokines and growth factors, are addressed in this review. SN - 0031-9333 UR - https://www.unboundmedicine.com/medline/citation/14506301/Role_of_monocytes_in_atherogenesis_ L2 - http://journals.physiology.org/doi/full/10.1152/physrev.00005.2003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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