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Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects.
Eur J Clin Nutr. 2003 Oct; 57(10):1268-74.EJ

Abstract

OBJECTIVE

To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects on body-weight maintenance, parameters of appetite and energy intake (EI) at breakfast after weight loss.

DESIGN

This study had a double-blind, placebo-controlled randomized design.

SUBJECTS

A total of 26 men and 28 women (age 37.8+/-7.7 y; body mass index 27.8+/-1.5 kg/m(2)).

INTERVENTIONS

Subjects were first submitted to a very-low-calorie diet (VLCD; 2.1 MJ/day) for 3 weeks after which they started with the 13-week intervention period. They either received 1.8 g CLA or placebo per day or 3.6 g CLA or placebo per day. Additionally, subjects of the high dosage intervention replaced their habitual lunch by one meal of a protein-rich, low-energy supplement. EI was measured at breakfast and appetite profile after an overnight fast.

RESULTS

The mean body weight loss was 6.9+/-1.7% of their original body weight. Multiple regression analysis showed that at the end of the 13-week intervention, CLA did not have an effect on body weight regain. Feelings of fullness and satiety were increased and feelings of hunger were decreased after 13 weeks intervention by CLA compared to placebo, independent of %body weight regain. However, EI measured at breakfast was not affected by CLA.

CONCLUSION

Appetite (hunger, satiety and fullness) was favorably, dose-independently affected by a 13-week consumption of 1.8 or 3.6 g CLA/day. This did not result in a lower EI at breakfast or an improved body-weight maintenance after weight loss.

Authors+Show Affiliations

Kamphuis MM
Department of Human Biology, Faculty of Health Sciences, Maastricht University, Maastricht, The Netherlands. M.Kamphuis@hb.unimaas.nl
Lejeune MP
No affiliation info available
Saris WH
No affiliation info available
Westerterp-Plantenga MS
No affiliation info available

MeSH

AdultAppetiteDiet, ReducingDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodEatingEnergy IntakeFemaleHumansLinoleic Acids, ConjugatedMaleMiddle AgedObesitySatiationWeight Loss

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14506488

Citation

Kamphuis, M M J W., et al. "Effect of Conjugated Linoleic Acid Supplementation After Weight Loss On Appetite and Food Intake in Overweight Subjects." European Journal of Clinical Nutrition, vol. 57, no. 10, 2003, pp. 1268-74.
Kamphuis MM, Lejeune MP, Saris WH, et al. Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Eur J Clin Nutr. 2003;57(10):1268-74.
Kamphuis, M. M., Lejeune, M. P., Saris, W. H., & Westerterp-Plantenga, M. S. (2003). Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. European Journal of Clinical Nutrition, 57(10), 1268-74.
Kamphuis MM, et al. Effect of Conjugated Linoleic Acid Supplementation After Weight Loss On Appetite and Food Intake in Overweight Subjects. Eur J Clin Nutr. 2003;57(10):1268-74. PubMed PMID: 14506488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. AU - Kamphuis,M M J W, AU - Lejeune,M P G M, AU - Saris,W H M, AU - Westerterp-Plantenga,M S, PY - 2003/9/25/pubmed PY - 2004/3/9/medline PY - 2003/9/25/entrez SP - 1268 EP - 74 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 10 N2 - OBJECTIVE: To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects on body-weight maintenance, parameters of appetite and energy intake (EI) at breakfast after weight loss. DESIGN: This study had a double-blind, placebo-controlled randomized design. SUBJECTS: A total of 26 men and 28 women (age 37.8+/-7.7 y; body mass index 27.8+/-1.5 kg/m(2)). INTERVENTIONS: Subjects were first submitted to a very-low-calorie diet (VLCD; 2.1 MJ/day) for 3 weeks after which they started with the 13-week intervention period. They either received 1.8 g CLA or placebo per day or 3.6 g CLA or placebo per day. Additionally, subjects of the high dosage intervention replaced their habitual lunch by one meal of a protein-rich, low-energy supplement. EI was measured at breakfast and appetite profile after an overnight fast. RESULTS: The mean body weight loss was 6.9+/-1.7% of their original body weight. Multiple regression analysis showed that at the end of the 13-week intervention, CLA did not have an effect on body weight regain. Feelings of fullness and satiety were increased and feelings of hunger were decreased after 13 weeks intervention by CLA compared to placebo, independent of %body weight regain. However, EI measured at breakfast was not affected by CLA. CONCLUSION: Appetite (hunger, satiety and fullness) was favorably, dose-independently affected by a 13-week consumption of 1.8 or 3.6 g CLA/day. This did not result in a lower EI at breakfast or an improved body-weight maintenance after weight loss. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14506488/Effect_of_conjugated_linoleic_acid_supplementation_after_weight_loss_on_appetite_and_food_intake_in_overweight_subjects_ DB - PRIME DP - Unbound Medicine ER -