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Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.

Abstract

To evaluate the effects of glucose metabolism related factors, such as insulin and insulin-like growth-factors (IGFs), on breast cancer development among Japanese women, we conducted a case-referent study comparing 187 women presenting with operable breast cancer and 190 women of the same age having no breast cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were determined by multiple logistic regression analysis. In the present study, no association in risk was observed with increasing levels of IGF-I or IGF binding protein-3 (IGFBP-3), before or after adjustment these factors. However, a suggestion of a positive association of an increased breast cancer risk was evident in postmenopausal women with elevated plasma insulin levels, particularly those with BMI>23.07. The OR for plasma insulin in the top tertile was 4.48 (95%CI:1.07-18.7) compared to the bottom tertile. For C-peptide, there was a similar positive association, with a corresponding OR of 2.28. In addition, we observed strong links between plasma insulin, C-peptide levels and estrogen receptor (ER) negative breast cancer, with ORs of 2.79(95%CI:1.09-7.16), and 2.52 (95%CI:0.91-6.97) respectively, for the top versus bottom tertiles. In conclusion, the present study suggested that plasma insulin level is a predictor of postmenopausal breast cancer in obese women and ER negative breast cancer. Additional studies are needed to clarify the role of glucose metabolism pathways in breast cancer development and interaction of IGF systems.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. khirose@aichi-cc.jp

    , , , ,

    Source

    MeSH

    Adult
    Blood Glucose
    Breast Neoplasms
    Case-Control Studies
    Female
    Humans
    Insulin
    Insulin-Like Growth Factor I
    Japan
    Logistic Models
    Middle Aged
    Premenopause
    Receptors, Progesterone
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14507245

    Citation

    Hirose, Kaoru, et al. "Insulin, Insulin-like Growth factor-I and Breast Cancer Risk in Japanese Women." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 4, no. 3, 2003, pp. 239-46.
    Hirose K, Toyama T, Iwata H, et al. Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pac J Cancer Prev. 2003;4(3):239-46.
    Hirose, K., Toyama, T., Iwata, H., Takezaki, T., Hamajima, N., & Tajima, K. (2003). Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pacific Journal of Cancer Prevention : APJCP, 4(3), pp. 239-46.
    Hirose K, et al. Insulin, Insulin-like Growth factor-I and Breast Cancer Risk in Japanese Women. Asian Pac J Cancer Prev. 2003;4(3):239-46. PubMed PMID: 14507245.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. AU - Hirose,Kaoru, AU - Toyama,Tatsuya, AU - Iwata,Hiroji, AU - Takezaki,Toshiro, AU - Hamajima,Nobuyuki, AU - Tajima,Kazuo, PY - 2003/9/26/pubmed PY - 2003/12/3/medline PY - 2003/9/26/entrez SP - 239 EP - 46 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 4 IS - 3 N2 - To evaluate the effects of glucose metabolism related factors, such as insulin and insulin-like growth-factors (IGFs), on breast cancer development among Japanese women, we conducted a case-referent study comparing 187 women presenting with operable breast cancer and 190 women of the same age having no breast cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were determined by multiple logistic regression analysis. In the present study, no association in risk was observed with increasing levels of IGF-I or IGF binding protein-3 (IGFBP-3), before or after adjustment these factors. However, a suggestion of a positive association of an increased breast cancer risk was evident in postmenopausal women with elevated plasma insulin levels, particularly those with BMI>23.07. The OR for plasma insulin in the top tertile was 4.48 (95%CI:1.07-18.7) compared to the bottom tertile. For C-peptide, there was a similar positive association, with a corresponding OR of 2.28. In addition, we observed strong links between plasma insulin, C-peptide levels and estrogen receptor (ER) negative breast cancer, with ORs of 2.79(95%CI:1.09-7.16), and 2.52 (95%CI:0.91-6.97) respectively, for the top versus bottom tertiles. In conclusion, the present study suggested that plasma insulin level is a predictor of postmenopausal breast cancer in obese women and ER negative breast cancer. Additional studies are needed to clarify the role of glucose metabolism pathways in breast cancer development and interaction of IGF systems. SN - 1513-7368 UR - https://www.unboundmedicine.com/medline/citation/14507245/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:14507245&key=2003.4.3.239 DB - PRIME DP - Unbound Medicine ER -