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Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.
Asian Pac J Cancer Prev 2003 Jul-Sep; 4(3):239-46AP

Abstract

To evaluate the effects of glucose metabolism related factors, such as insulin and insulin-like growth-factors (IGFs), on breast cancer development among Japanese women, we conducted a case-referent study comparing 187 women presenting with operable breast cancer and 190 women of the same age having no breast cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were determined by multiple logistic regression analysis. In the present study, no association in risk was observed with increasing levels of IGF-I or IGF binding protein-3 (IGFBP-3), before or after adjustment these factors. However, a suggestion of a positive association of an increased breast cancer risk was evident in postmenopausal women with elevated plasma insulin levels, particularly those with BMI>23.07. The OR for plasma insulin in the top tertile was 4.48 (95%CI:1.07-18.7) compared to the bottom tertile. For C-peptide, there was a similar positive association, with a corresponding OR of 2.28. In addition, we observed strong links between plasma insulin, C-peptide levels and estrogen receptor (ER) negative breast cancer, with ORs of 2.79(95%CI:1.09-7.16), and 2.52 (95%CI:0.91-6.97) respectively, for the top versus bottom tertiles. In conclusion, the present study suggested that plasma insulin level is a predictor of postmenopausal breast cancer in obese women and ER negative breast cancer. Additional studies are needed to clarify the role of glucose metabolism pathways in breast cancer development and interaction of IGF systems.

Authors+Show Affiliations

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. khirose@aichi-cc.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14507245

Citation

Hirose, Kaoru, et al. "Insulin, Insulin-like Growth factor-I and Breast Cancer Risk in Japanese Women." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 4, no. 3, 2003, pp. 239-46.
Hirose K, Toyama T, Iwata H, et al. Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pac J Cancer Prev. 2003;4(3):239-46.
Hirose, K., Toyama, T., Iwata, H., Takezaki, T., Hamajima, N., & Tajima, K. (2003). Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pacific Journal of Cancer Prevention : APJCP, 4(3), pp. 239-46.
Hirose K, et al. Insulin, Insulin-like Growth factor-I and Breast Cancer Risk in Japanese Women. Asian Pac J Cancer Prev. 2003;4(3):239-46. PubMed PMID: 14507245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. AU - Hirose,Kaoru, AU - Toyama,Tatsuya, AU - Iwata,Hiroji, AU - Takezaki,Toshiro, AU - Hamajima,Nobuyuki, AU - Tajima,Kazuo, PY - 2003/9/26/pubmed PY - 2003/12/3/medline PY - 2003/9/26/entrez SP - 239 EP - 46 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 4 IS - 3 N2 - To evaluate the effects of glucose metabolism related factors, such as insulin and insulin-like growth-factors (IGFs), on breast cancer development among Japanese women, we conducted a case-referent study comparing 187 women presenting with operable breast cancer and 190 women of the same age having no breast cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were determined by multiple logistic regression analysis. In the present study, no association in risk was observed with increasing levels of IGF-I or IGF binding protein-3 (IGFBP-3), before or after adjustment these factors. However, a suggestion of a positive association of an increased breast cancer risk was evident in postmenopausal women with elevated plasma insulin levels, particularly those with BMI>23.07. The OR for plasma insulin in the top tertile was 4.48 (95%CI:1.07-18.7) compared to the bottom tertile. For C-peptide, there was a similar positive association, with a corresponding OR of 2.28. In addition, we observed strong links between plasma insulin, C-peptide levels and estrogen receptor (ER) negative breast cancer, with ORs of 2.79(95%CI:1.09-7.16), and 2.52 (95%CI:0.91-6.97) respectively, for the top versus bottom tertiles. In conclusion, the present study suggested that plasma insulin level is a predictor of postmenopausal breast cancer in obese women and ER negative breast cancer. Additional studies are needed to clarify the role of glucose metabolism pathways in breast cancer development and interaction of IGF systems. SN - 1513-7368 UR - https://www.unboundmedicine.com/medline/citation/14507245/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:14507245&key=2003.4.3.239 DB - PRIME DP - Unbound Medicine ER -