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[Therapeutic characteristance and tolerance of topical comfrey preparations. Results of an observational study of patients].
Fortschr Med Orig 2002; 120(1):1-9FM

Abstract

AIM

To analyze the anti-inflammatory and analgetic properties of the topical comfrey, preparations Kytta-Salbe f, Kytta-Plasma f and Kytta-Balsam f applied to bruises, sprains and distortions and painful conditions of the muscles and joints.

METHOD

A prospective open multicentric observational study complying with paragraph 67(6) of the AMG and involving 162 general practitioners. During the two-week period of observation, the patients received an average of one to three applications of the comfrey preparation per day. All 492 questionnaires were evaluated. Efficacy and tolerability were assessed by both physician and patient.

RESULTS

Pain at rest and on movement, as also tenderness, improved in the overall observation group by an average of 45-47%. The duration of morning joint stiffness decreased from 20 minutes initially to 3 minutes. During the course of treatment with comfrey, more than two-thirds of the patients were able to reduce or even discontinue their intake of non-steroidal anti-inflammatory drugs and other specific concomitant medication. In most of the cases, both effectiveness and tolerability were assessed to be excellent or good.

CONCLUSION

The results of the study confirm the effectiveness and tolerability of the topical comfrey preparation investigated in the treatment of bruises, sprains and distortions as well as painful conditions affecting muscles and joints.

Authors+Show Affiliations

Merck Selbstmedikation GmbH, Darmstadt.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study

Language

ger

PubMed ID

14518351

Citation

Koll, R, and S Klingenburg. "[Therapeutic Characteristance and Tolerance of Topical Comfrey Preparations. Results of an Observational Study of Patients]." Fortschritte Der Medizin. Originalien, vol. 120, no. 1, 2002, pp. 1-9.
Koll R, Klingenburg S. [Therapeutic characteristance and tolerance of topical comfrey preparations. Results of an observational study of patients]. Fortschr Med Orig. 2002;120(1):1-9.
Koll, R., & Klingenburg, S. (2002). [Therapeutic characteristance and tolerance of topical comfrey preparations. Results of an observational study of patients]. Fortschritte Der Medizin. Originalien, 120(1), pp. 1-9.
Koll R, Klingenburg S. [Therapeutic Characteristance and Tolerance of Topical Comfrey Preparations. Results of an Observational Study of Patients]. Fortschr Med Orig. 2002;120(1):1-9. PubMed PMID: 14518351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Therapeutic characteristance and tolerance of topical comfrey preparations. Results of an observational study of patients]. AU - Koll,R, AU - Klingenburg,S, PY - 2003/10/2/pubmed PY - 2004/1/9/medline PY - 2003/10/2/entrez SP - 1 EP - 9 JF - Fortschritte der Medizin. Originalien JO - Fortschr Med Orig VL - 120 IS - 1 N2 - AIM: To analyze the anti-inflammatory and analgetic properties of the topical comfrey, preparations Kytta-Salbe f, Kytta-Plasma f and Kytta-Balsam f applied to bruises, sprains and distortions and painful conditions of the muscles and joints. METHOD: A prospective open multicentric observational study complying with paragraph 67(6) of the AMG and involving 162 general practitioners. During the two-week period of observation, the patients received an average of one to three applications of the comfrey preparation per day. All 492 questionnaires were evaluated. Efficacy and tolerability were assessed by both physician and patient. RESULTS: Pain at rest and on movement, as also tenderness, improved in the overall observation group by an average of 45-47%. The duration of morning joint stiffness decreased from 20 minutes initially to 3 minutes. During the course of treatment with comfrey, more than two-thirds of the patients were able to reduce or even discontinue their intake of non-steroidal anti-inflammatory drugs and other specific concomitant medication. In most of the cases, both effectiveness and tolerability were assessed to be excellent or good. CONCLUSION: The results of the study confirm the effectiveness and tolerability of the topical comfrey preparation investigated in the treatment of bruises, sprains and distortions as well as painful conditions affecting muscles and joints. UR - https://www.unboundmedicine.com/medline/citation/14518351/[Therapeutic_characteristance_and_tolerance_of_topical_comfrey_preparations__Results_of_an_observational_study_of_patients]_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -