Tags

Type your tag names separated by a space and hit enter

Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain.
J Orofac Pain. 2003 Summer; 17(3):237-44.JO

Abstract

AIMS

To compare the efficacy and safety of diclofenac-K (12.5 mg) vs paracetamol (500 mg) and placebo given in a flexible dosage regimen to treat pain resulting from extraction of impacted third molar teeth.

METHODS

This was a 2-day, double-blind, double-dummy, randomized, parallel-group, placebo-controlled study of diclofenac-K (12.5 mg) tablets vs paracetamol (500 mg) tablets and placebo in patients with moderate or severe pain within 8 hours of extraction of impacted third molars.

RESULTS

After the first 2-tablet dose, patients took on average 2.5 additional tablets of diclofenac-K or 2.4 tablets of paracetamol, almost all as 1-tablet doses. Most placebo patients discontinued by taking rescue medication (ibuprofen 200 mg) on the first day. Pain relief after the initial dose of diclofenac-K (2 x 12.5 mg) was superior to placebo (P < .01 for all efficacy outcomes) and comparable to paracetamol (2 x 500 mg). About 30% of patients in each active treatment group took rescue medication during the study, compared to 78% on placebo. About 70% in each active treatment group considered the overall pain relief to be "some," "a lot," or "complete" compared to only 15% on placebo. The incidence of adverse events in each active treatment group was low and comparable between the treatments.

CONCLUSION

An initial double-dose of diclofenac-K (2 x 12.5 mg) or paracetamol (2 x 500 mg) adequately relieved the most intense postoperative pain, and the flexible multiple dose regimen (1 or 2 tablets) maintained adequate pain relief thereafter. Most patients needed only 1-tablet doses following the initial 2-tablet dose.

Authors+Show Affiliations

Clinical Research and Development of Pharmaceuticals, Morge, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14520769

Citation

Kubitzek, Florian, et al. "Analgesic Efficacy of Low-dose Diclofenac Versus Paracetamol and Placebo in Postoperative Dental Pain." Journal of Orofacial Pain, vol. 17, no. 3, 2003, pp. 237-44.
Kubitzek F, Ziegler G, Gold MS, et al. Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain. J Orofac Pain. 2003;17(3):237-44.
Kubitzek, F., Ziegler, G., Gold, M. S., Liu, J. M., & Ionescu, E. (2003). Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain. Journal of Orofacial Pain, 17(3), 237-44.
Kubitzek F, et al. Analgesic Efficacy of Low-dose Diclofenac Versus Paracetamol and Placebo in Postoperative Dental Pain. J Orofac Pain. 2003;17(3):237-44. PubMed PMID: 14520769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain. AU - Kubitzek,Florian, AU - Ziegler,Gabrielle, AU - Gold,Morris S, AU - Liu,Jiun-Min-H, AU - Ionescu,Elisabeta, PY - 2003/10/3/pubmed PY - 2003/12/3/medline PY - 2003/10/3/entrez SP - 237 EP - 44 JF - Journal of orofacial pain JO - J Orofac Pain VL - 17 IS - 3 N2 - AIMS: To compare the efficacy and safety of diclofenac-K (12.5 mg) vs paracetamol (500 mg) and placebo given in a flexible dosage regimen to treat pain resulting from extraction of impacted third molar teeth. METHODS: This was a 2-day, double-blind, double-dummy, randomized, parallel-group, placebo-controlled study of diclofenac-K (12.5 mg) tablets vs paracetamol (500 mg) tablets and placebo in patients with moderate or severe pain within 8 hours of extraction of impacted third molars. RESULTS: After the first 2-tablet dose, patients took on average 2.5 additional tablets of diclofenac-K or 2.4 tablets of paracetamol, almost all as 1-tablet doses. Most placebo patients discontinued by taking rescue medication (ibuprofen 200 mg) on the first day. Pain relief after the initial dose of diclofenac-K (2 x 12.5 mg) was superior to placebo (P < .01 for all efficacy outcomes) and comparable to paracetamol (2 x 500 mg). About 30% of patients in each active treatment group took rescue medication during the study, compared to 78% on placebo. About 70% in each active treatment group considered the overall pain relief to be "some," "a lot," or "complete" compared to only 15% on placebo. The incidence of adverse events in each active treatment group was low and comparable between the treatments. CONCLUSION: An initial double-dose of diclofenac-K (2 x 12.5 mg) or paracetamol (2 x 500 mg) adequately relieved the most intense postoperative pain, and the flexible multiple dose regimen (1 or 2 tablets) maintained adequate pain relief thereafter. Most patients needed only 1-tablet doses following the initial 2-tablet dose. SN - 1064-6655 UR - https://www.unboundmedicine.com/medline/citation/14520769/Analgesic_efficacy_of_low_dose_diclofenac_versus_paracetamol_and_placebo_in_postoperative_dental_pain_ L2 - https://medlineplus.gov/painrelievers.html DB - PRIME DP - Unbound Medicine ER -