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Is memantine a breakthrough in the treatment of moderate-to-severe Alzheimer's disease?

Abstract

Over stimulation of the NMDA receptor by glutamate has long been considered to have a role in Alzheimer's disease (AD). Memantine, a non-competitive antagonist of NMDA receptors, has recently been tested in moderate-to-severe AD. At 28 weeks, there was a small significant mean difference of 0.3 in favour of memantine, showing benefit in the Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) global score. The other primary efficacy variable was the Alzheimer's disease Cooperative Study Activities of Daily Living Inventory, modified for more severe dementia (ADCS-ADL-sev) and there was significantly less deterioration in the ADCSADL-sev score in the memantine group than in the placebo group (2.1 versus 3.4, respectively). As there are no drugs commonly used for their effectiveness in moderate-to-severe AD, any drug that causes a benefit, however small, as memantine has been shown to do in this trial, represents a breakthrough.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand. s_doggrell@yahoo.co

    Source

    Expert opinion on pharmacotherapy 4:10 2003 Oct pg 1857-60

    MeSH

    Alzheimer Disease
    Clinical Trials as Topic
    Humans
    Memantine
    Receptors, N-Methyl-D-Aspartate
    Severity of Illness Index
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    14521495

    Citation

    Doggrell, Sheila. "Is Memantine a Breakthrough in the Treatment of Moderate-to-severe Alzheimer's Disease?" Expert Opinion On Pharmacotherapy, vol. 4, no. 10, 2003, pp. 1857-60.
    Doggrell S. Is memantine a breakthrough in the treatment of moderate-to-severe Alzheimer's disease? Expert Opin Pharmacother. 2003;4(10):1857-60.
    Doggrell, S. (2003). Is memantine a breakthrough in the treatment of moderate-to-severe Alzheimer's disease? Expert Opinion On Pharmacotherapy, 4(10), pp. 1857-60.
    Doggrell S. Is Memantine a Breakthrough in the Treatment of Moderate-to-severe Alzheimer's Disease. Expert Opin Pharmacother. 2003;4(10):1857-60. PubMed PMID: 14521495.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is memantine a breakthrough in the treatment of moderate-to-severe Alzheimer's disease? A1 - Doggrell,Sheila, PY - 2003/10/3/pubmed PY - 2003/12/19/medline PY - 2003/10/3/entrez SP - 1857 EP - 60 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 4 IS - 10 N2 - Over stimulation of the NMDA receptor by glutamate has long been considered to have a role in Alzheimer's disease (AD). Memantine, a non-competitive antagonist of NMDA receptors, has recently been tested in moderate-to-severe AD. At 28 weeks, there was a small significant mean difference of 0.3 in favour of memantine, showing benefit in the Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) global score. The other primary efficacy variable was the Alzheimer's disease Cooperative Study Activities of Daily Living Inventory, modified for more severe dementia (ADCS-ADL-sev) and there was significantly less deterioration in the ADCSADL-sev score in the memantine group than in the placebo group (2.1 versus 3.4, respectively). As there are no drugs commonly used for their effectiveness in moderate-to-severe AD, any drug that causes a benefit, however small, as memantine has been shown to do in this trial, represents a breakthrough. SN - 1465-6566 UR - https://www.unboundmedicine.com/medline/citation/14521495/Is_memantine_a_breakthrough_in_the_treatment_of_moderate_to_severe_Alzheimer's_disease L2 - http://www.tandfonline.com/doi/full/10.1517/14656566.4.10.1857 DB - PRIME DP - Unbound Medicine ER -