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Protective effects of the angiotensin II type 1 (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats.
Clin Sci (Lond). 2004 Mar; 106(3):251-9.CS

Abstract

The present study evaluates the participation of oxidative stress, tissue angiotensin II (Ang II) and endothelin (ET) in the effects of losartan on blood pressure (BP), ventricular hypertrophy and renal injury in spontaneously hypertensive rats (SHRs), and explores how these effects are modified when spontaneous hypertension is transformed in a low-renin model by the administration of deoxycorticosterone acetate (DOCA). The following groups were used: SHR-control, SHR+DOCA, SHR+losartan and SHR+DOCA+losartan. Tail systolic BP was measured once a week. After 9 weeks of treatment, direct BP and metabolic, morphological, biochemical and renal variables were measured. DOCA administration to SHRs produced an increase in BP, ventricular hypertrophy, renal weight, proteinuria, renal histopathological lesions, urinary excretion of isoprostane F2alpha and ET levels in the renal cortex. Losartan reduced BP, plasma malondialdehyde levels, urinary excretion of isoprostane F2alpha, renal Ang II and renal and urinary levels of ET in the SHR and DOCA-treated SHR groups. Losartan increased plasma nitrite/nitrate in SHRs, but not in low-renin DOCA-treated SHRs. Losartan reduced ventricular hypertrophy and ventricular Ang II in SHRs, but not in DOCA-treated SHRs. Losartan significantly decreased proteinuria and renal injury in DOCA-treated SHRs. We conclude that (i) the DOCA-induced aggravation of hypertension, ventricular hypertrophy and renal injury in SHRs is accompanied by augmented oxidative stress and increased levels of ET in the renal cortex, which could contribute to their development; and (ii) losartan reduced oxidative stress and renal Ang II and ET in SHRs and DOCA-treated SHRs, which might contribute to its antihypertensive and renoprotective effects, regardless of renin status.

Authors+Show Affiliations

Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14521506

Citation

Chamorro, Virginia, et al. "Protective Effects of the Angiotensin II Type 1 (AT1) Receptor Blockade in Low-renin Deoxycorticosterone Acetate (DOCA)-treated Spontaneously Hypertensive Rats." Clinical Science (London, England : 1979), vol. 106, no. 3, 2004, pp. 251-9.
Chamorro V, Wangensteen R, Sainz J, et al. Protective effects of the angiotensin II type 1 (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats. Clin Sci (Lond). 2004;106(3):251-9.
Chamorro, V., Wangensteen, R., Sainz, J., Duarte, J., O'Valle, F., Osuna, A., & Vargas, F. (2004). Protective effects of the angiotensin II type 1 (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats. Clinical Science (London, England : 1979), 106(3), 251-9.
Chamorro V, et al. Protective Effects of the Angiotensin II Type 1 (AT1) Receptor Blockade in Low-renin Deoxycorticosterone Acetate (DOCA)-treated Spontaneously Hypertensive Rats. Clin Sci (Lond). 2004;106(3):251-9. PubMed PMID: 14521506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of the angiotensin II type 1 (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats. AU - Chamorro,Virginia, AU - Wangensteen,Rosemary, AU - Sainz,Juan, AU - Duarte,Juan, AU - O'Valle,Francisco, AU - Osuna,Antonio, AU - Vargas,Félix, PY - 2003/10/02/accepted PY - 2003/09/09/received PY - 2003/10/3/pubmed PY - 2004/5/5/medline PY - 2003/10/3/entrez SP - 251 EP - 9 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 106 IS - 3 N2 - The present study evaluates the participation of oxidative stress, tissue angiotensin II (Ang II) and endothelin (ET) in the effects of losartan on blood pressure (BP), ventricular hypertrophy and renal injury in spontaneously hypertensive rats (SHRs), and explores how these effects are modified when spontaneous hypertension is transformed in a low-renin model by the administration of deoxycorticosterone acetate (DOCA). The following groups were used: SHR-control, SHR+DOCA, SHR+losartan and SHR+DOCA+losartan. Tail systolic BP was measured once a week. After 9 weeks of treatment, direct BP and metabolic, morphological, biochemical and renal variables were measured. DOCA administration to SHRs produced an increase in BP, ventricular hypertrophy, renal weight, proteinuria, renal histopathological lesions, urinary excretion of isoprostane F2alpha and ET levels in the renal cortex. Losartan reduced BP, plasma malondialdehyde levels, urinary excretion of isoprostane F2alpha, renal Ang II and renal and urinary levels of ET in the SHR and DOCA-treated SHR groups. Losartan increased plasma nitrite/nitrate in SHRs, but not in low-renin DOCA-treated SHRs. Losartan reduced ventricular hypertrophy and ventricular Ang II in SHRs, but not in DOCA-treated SHRs. Losartan significantly decreased proteinuria and renal injury in DOCA-treated SHRs. We conclude that (i) the DOCA-induced aggravation of hypertension, ventricular hypertrophy and renal injury in SHRs is accompanied by augmented oxidative stress and increased levels of ET in the renal cortex, which could contribute to their development; and (ii) losartan reduced oxidative stress and renal Ang II and ET in SHRs and DOCA-treated SHRs, which might contribute to its antihypertensive and renoprotective effects, regardless of renin status. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/14521506/Protective_effects_of_the_angiotensin_II_type_1__AT1__receptor_blockade_in_low_renin_deoxycorticosterone_acetate__DOCA__treated_spontaneously_hypertensive_rats_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20030299 DB - PRIME DP - Unbound Medicine ER -