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Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes.
Ophthalmology. 2003 Oct; 110(10):1903-8.O

Abstract

OBJECTIVE

It has been suggested that some patients currently diagnosed with ocular hypertension (OHT) may have thicker than average corneas that result in an overestimation of their true intraocular pressure. Consequently, patients with OHT with greater corneal thickness may be at a lower risk for functional glaucomatous damage, including visual field loss measured with frequency doubling technology (FDT) perimetry. The purpose of this study was to evaluate the frequency of FDT perimetry deficits in patients with OHT and to correlate these findings with central corneal thickness (CCT) measurements.

DESIGN

Observational case control study.

PARTICIPANTS AND CONTROLS

Sixty-five patients with OHT with normal optic discs and normal standard achromatic automated perimetry (SAP) visual fields and 52 normal control subjects.

METHODS

All participants underwent SAP, FDT perimetry, and CCT measurements using ultrasound pachymetry.

MAIN OUTCOME MEASURES

CCT measurements in patients with OHT with abnormal repeatable FDT test results were compared with CCT measurements in patients with OHT with normal FDT results. In addition, CCT measurements in patients with OHT were compared with CCT measurements in normal control subjects.

RESULTS

Fourteen of 65 patients with OHT (21.5%) demonstrated repeatable FDT abnormalities. The mean CCT of patients with OHT with abnormal FDT results was significantly lower than the mean CCT of patients with OHT with normal FDT results (542+/-35 microm versus 575+/-35 microm; P = 0.003). The mean CCT in the normal control group was 556+/-36 microm. The mean CCT in patients with OHT with normal FDT results was significantly higher than in normal subjects (P = 0.008). No statistically significant difference was found between mean CCT in normal subjects and in patients with OHT with abnormal FDT results (P = 0.18).

CONCLUSIONS

Patients currently diagnosed with OHT, but with visual field loss detected by FDT perimetry, had significantly lower CCT measurements than patients with OHT with normal FDT results. These findings suggest that patients with OHT with thinner corneas are more likely to develop early glaucomatous functional damage and that CCT measurements should be taken into account when assessing risk for the development of glaucoma among OHT subjects.

Authors+Show Affiliations

Hamilton Glaucoma Center and Visual Function Laboratory, Department of Ophthalmology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14522761

Citation

Medeiros, Felipe A., et al. "Corneal Thickness Measurements and Frequency Doubling Technology Perimetry Abnormalities in Ocular Hypertensive Eyes." Ophthalmology, vol. 110, no. 10, 2003, pp. 1903-8.
Medeiros FA, Sample PA, Weinreb RN. Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes. Ophthalmology. 2003;110(10):1903-8.
Medeiros, F. A., Sample, P. A., & Weinreb, R. N. (2003). Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes. Ophthalmology, 110(10), 1903-8.
Medeiros FA, Sample PA, Weinreb RN. Corneal Thickness Measurements and Frequency Doubling Technology Perimetry Abnormalities in Ocular Hypertensive Eyes. Ophthalmology. 2003;110(10):1903-8. PubMed PMID: 14522761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes. AU - Medeiros,Felipe A, AU - Sample,Pamela A, AU - Weinreb,Robert N, PY - 2003/10/3/pubmed PY - 2003/10/31/medline PY - 2003/10/3/entrez SP - 1903 EP - 8 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 10 N2 - OBJECTIVE: It has been suggested that some patients currently diagnosed with ocular hypertension (OHT) may have thicker than average corneas that result in an overestimation of their true intraocular pressure. Consequently, patients with OHT with greater corneal thickness may be at a lower risk for functional glaucomatous damage, including visual field loss measured with frequency doubling technology (FDT) perimetry. The purpose of this study was to evaluate the frequency of FDT perimetry deficits in patients with OHT and to correlate these findings with central corneal thickness (CCT) measurements. DESIGN: Observational case control study. PARTICIPANTS AND CONTROLS: Sixty-five patients with OHT with normal optic discs and normal standard achromatic automated perimetry (SAP) visual fields and 52 normal control subjects. METHODS: All participants underwent SAP, FDT perimetry, and CCT measurements using ultrasound pachymetry. MAIN OUTCOME MEASURES: CCT measurements in patients with OHT with abnormal repeatable FDT test results were compared with CCT measurements in patients with OHT with normal FDT results. In addition, CCT measurements in patients with OHT were compared with CCT measurements in normal control subjects. RESULTS: Fourteen of 65 patients with OHT (21.5%) demonstrated repeatable FDT abnormalities. The mean CCT of patients with OHT with abnormal FDT results was significantly lower than the mean CCT of patients with OHT with normal FDT results (542+/-35 microm versus 575+/-35 microm; P = 0.003). The mean CCT in the normal control group was 556+/-36 microm. The mean CCT in patients with OHT with normal FDT results was significantly higher than in normal subjects (P = 0.008). No statistically significant difference was found between mean CCT in normal subjects and in patients with OHT with abnormal FDT results (P = 0.18). CONCLUSIONS: Patients currently diagnosed with OHT, but with visual field loss detected by FDT perimetry, had significantly lower CCT measurements than patients with OHT with normal FDT results. These findings suggest that patients with OHT with thinner corneas are more likely to develop early glaucomatous functional damage and that CCT measurements should be taken into account when assessing risk for the development of glaucoma among OHT subjects. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/14522761/Corneal_thickness_measurements_and_frequency_doubling_technology_perimetry_abnormalities_in_ocular_hypertensive_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(03)00734-6 DB - PRIME DP - Unbound Medicine ER -