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Androgen receptor in human skin.
Br J Dermatol. 1977 Nov; 97(5):501-3.BJ

Abstract

Cytosol androgen receptor was assayed in 18 human skin biopsies by an exchange technique with a labelled potent synthetic androgen, methyltrienolone (R 1881), under conditions which measured total (i.e. both free and occupied) binding sites. Androgen binding sites were only present in skin biopsies from patients with marked seborrhoea often accompanied by acne (8 cases) and no sites were detected in normal skin biopsies (7 cases). Three biopsies from seborrhoeic patients, however, did not contain androgen receptor. Although no direct quantitative correlation could be drawn between binding site concentration and sebum excretion, it would seem that the androgen receptor content nevertheless constitutes an important parameter in the study of the hormonal control of seborrhoea.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

145235

Citation

Bonne, C, et al. "Androgen Receptor in Human Skin." The British Journal of Dermatology, vol. 97, no. 5, 1977, pp. 501-3.
Bonne C, Saurat JH, Chivot M, et al. Androgen receptor in human skin. Br J Dermatol. 1977;97(5):501-3.
Bonne, C., Saurat, J. H., Chivot, M., Lehuchet, D., & Raynaud, J. P. (1977). Androgen receptor in human skin. The British Journal of Dermatology, 97(5), 501-3.
Bonne C, et al. Androgen Receptor in Human Skin. Br J Dermatol. 1977;97(5):501-3. PubMed PMID: 145235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgen receptor in human skin. AU - Bonne,C, AU - Saurat,J H, AU - Chivot,M, AU - Lehuchet,D, AU - Raynaud,J P, PY - 1977/11/1/pubmed PY - 1977/11/1/medline PY - 1977/11/1/entrez SP - 501 EP - 3 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 97 IS - 5 N2 - Cytosol androgen receptor was assayed in 18 human skin biopsies by an exchange technique with a labelled potent synthetic androgen, methyltrienolone (R 1881), under conditions which measured total (i.e. both free and occupied) binding sites. Androgen binding sites were only present in skin biopsies from patients with marked seborrhoea often accompanied by acne (8 cases) and no sites were detected in normal skin biopsies (7 cases). Three biopsies from seborrhoeic patients, however, did not contain androgen receptor. Although no direct quantitative correlation could be drawn between binding site concentration and sebum excretion, it would seem that the androgen receptor content nevertheless constitutes an important parameter in the study of the hormonal control of seborrhoea. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/145235/Androgen_receptor_in_human_skin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1977&volume=97&issue=5&spage=501 DB - PRIME DP - Unbound Medicine ER -