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Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection: a 9-year cohort study in rural Japan.
Clin Infect Dis. 2003 Oct 15; 37(8):1067-72.CI

Abstract

We compared the seroepidemiologic patterns of Helicobacter pylori and hepatitis A virus (HAV) infections among participants in 2 independent cross-sectional studies conducted in Japan in 1986 and 1994. Subgroups were monitored with successive blood sampling. H. pylori and HAV infection status was defined by results of enzyme-linked immunosorbent assay. In 1986, the prevalence of H. pylori infection and HAV infection, respectively, were 80% and 70% among adults and 31% and 5% among children. The prevalence of both infections increased with age. Concordant infections were found in 74.5% of adults (kappa=0.2) versus 2% of children (kappa=0.05). During the 9-year study period, the incidence of H. pylori infection was 1.1% among adults and 2% among children. The seroprevalence of HAV remained constant. The disparity between the increase in prevalence of H. pylori and HAV infection with age is likely associated with improvements in hygienic practices. The discordance between the presence of the infections among younger persons is evidence against a common source and/or vehicle for transmission.

Authors+Show Affiliations

Department of Medicine, Veterans Affair Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA. Hmalaty@bcm.tmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14523771

Citation

Malaty, Hoda M., et al. "Seroepidemiology of Helicobacter Pylori and Hepatitis a Virus and the Mode of Transmission of Infection: a 9-year Cohort Study in Rural Japan." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 37, no. 8, 2003, pp. 1067-72.
Malaty HM, Tanaka E, Kumagai T, et al. Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection: a 9-year cohort study in rural Japan. Clin Infect Dis. 2003;37(8):1067-72.
Malaty, H. M., Tanaka, E., Kumagai, T., Ota, H., Kiyosawa, K., Graham, D. Y., & Katsuyama, T. (2003). Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection: a 9-year cohort study in rural Japan. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 37(8), 1067-72.
Malaty HM, et al. Seroepidemiology of Helicobacter Pylori and Hepatitis a Virus and the Mode of Transmission of Infection: a 9-year Cohort Study in Rural Japan. Clin Infect Dis. 2003 Oct 15;37(8):1067-72. PubMed PMID: 14523771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection: a 9-year cohort study in rural Japan. AU - Malaty,Hoda M, AU - Tanaka,Eiji, AU - Kumagai,Toshiko, AU - Ota,Hiroyoshi, AU - Kiyosawa,Kendo, AU - Graham,David Y, AU - Katsuyama,Tsutomu, Y1 - 2003/09/23/ PY - 2003/02/03/received PY - 2003/06/12/accepted PY - 2003/10/3/pubmed PY - 2003/12/3/medline PY - 2003/10/3/entrez SP - 1067 EP - 72 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 37 IS - 8 N2 - We compared the seroepidemiologic patterns of Helicobacter pylori and hepatitis A virus (HAV) infections among participants in 2 independent cross-sectional studies conducted in Japan in 1986 and 1994. Subgroups were monitored with successive blood sampling. H. pylori and HAV infection status was defined by results of enzyme-linked immunosorbent assay. In 1986, the prevalence of H. pylori infection and HAV infection, respectively, were 80% and 70% among adults and 31% and 5% among children. The prevalence of both infections increased with age. Concordant infections were found in 74.5% of adults (kappa=0.2) versus 2% of children (kappa=0.05). During the 9-year study period, the incidence of H. pylori infection was 1.1% among adults and 2% among children. The seroprevalence of HAV remained constant. The disparity between the increase in prevalence of H. pylori and HAV infection with age is likely associated with improvements in hygienic practices. The discordance between the presence of the infections among younger persons is evidence against a common source and/or vehicle for transmission. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/14523771/Seroepidemiology_of_Helicobacter_pylori_and_hepatitis_A_virus_and_the_mode_of_transmission_of_infection:_a_9_year_cohort_study_in_rural_Japan_ DB - PRIME DP - Unbound Medicine ER -