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Prevalence of antibodies against alpha-fodrin in Sjögren's syndrome: comparison of 2 sets of classification criteria.
J Rheumatol. 2003 Oct; 30(10):2157-9.JR

Abstract

OBJECTIVE

To compare the prevalence of antibodies against alpha-fodrin in Sjögren's syndrome (SS) classified according to San Diego and European Community Study Group (ESG) criteria.

METHODS

The prevalence and mean concentrations of IgA and IgG autoantibodies against alpha-fodrin were determined and compared in patients with SS classified either according to San Diego criteria or to criteria of the ESG by ELISA.

RESULTS

IgA antibodies against alpha-fodrin were detected in 88% and IgG antibodies against alpha-fodrin in 64% and either of these antibodies in 93% of 85 patients classified according to San Diego criteria. Antibodies against Ro were present in 38% of these sera. IgA antibodies against alpha-fodrin were detected in 61%, IgG antibodies against alpha-fodrin in 51%, and any of these antibodies in 73% of 51 patients classified according to the ESG criteria. The mean concentrations of both IgA and IgG antibodies against alpha-fodrin that seem to correlate with disease activity were higher in patients classified according to the San Diego criteria.

CONCLUSION

Antibodies against alpha-fodrin are detectable in almost all sera obtained from patients with SS classified according to the San Diego criteria and are significantly more prevalent than antibodies against Ro. The lower prevalence of the autoantibodies in patients classified according to the ESG criteria reflects the lower specificity of these criteria for SS.

Authors+Show Affiliations

Abteilung Klinische Immunologie, Medizinische Hochschule, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. witte.torsten@mh.hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14528510

Citation

Witte, Torsten, et al. "Prevalence of Antibodies Against Alpha-fodrin in Sjögren's Syndrome: Comparison of 2 Sets of Classification Criteria." The Journal of Rheumatology, vol. 30, no. 10, 2003, pp. 2157-9.
Witte T, Matthias T, Oppermann M, et al. Prevalence of antibodies against alpha-fodrin in Sjögren's syndrome: comparison of 2 sets of classification criteria. J Rheumatol. 2003;30(10):2157-9.
Witte, T., Matthias, T., Oppermann, M., Helmke, K., Peter, H. H., Schmidt, R. E., & Tishler, M. (2003). Prevalence of antibodies against alpha-fodrin in Sjögren's syndrome: comparison of 2 sets of classification criteria. The Journal of Rheumatology, 30(10), 2157-9.
Witte T, et al. Prevalence of Antibodies Against Alpha-fodrin in Sjögren's Syndrome: Comparison of 2 Sets of Classification Criteria. J Rheumatol. 2003;30(10):2157-9. PubMed PMID: 14528510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of antibodies against alpha-fodrin in Sjögren's syndrome: comparison of 2 sets of classification criteria. AU - Witte,Torsten, AU - Matthias,Torsten, AU - Oppermann,Martina, AU - Helmke,Klaus, AU - Peter,Hans H, AU - Schmidt,Reinhold E, AU - Tishler,Moshe, PY - 2003/10/7/pubmed PY - 2004/2/5/medline PY - 2003/10/7/entrez SP - 2157 EP - 9 JF - The Journal of rheumatology JO - J Rheumatol VL - 30 IS - 10 N2 - OBJECTIVE: To compare the prevalence of antibodies against alpha-fodrin in Sjögren's syndrome (SS) classified according to San Diego and European Community Study Group (ESG) criteria. METHODS: The prevalence and mean concentrations of IgA and IgG autoantibodies against alpha-fodrin were determined and compared in patients with SS classified either according to San Diego criteria or to criteria of the ESG by ELISA. RESULTS: IgA antibodies against alpha-fodrin were detected in 88% and IgG antibodies against alpha-fodrin in 64% and either of these antibodies in 93% of 85 patients classified according to San Diego criteria. Antibodies against Ro were present in 38% of these sera. IgA antibodies against alpha-fodrin were detected in 61%, IgG antibodies against alpha-fodrin in 51%, and any of these antibodies in 73% of 51 patients classified according to the ESG criteria. The mean concentrations of both IgA and IgG antibodies against alpha-fodrin that seem to correlate with disease activity were higher in patients classified according to the San Diego criteria. CONCLUSION: Antibodies against alpha-fodrin are detectable in almost all sera obtained from patients with SS classified according to the San Diego criteria and are significantly more prevalent than antibodies against Ro. The lower prevalence of the autoantibodies in patients classified according to the ESG criteria reflects the lower specificity of these criteria for SS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/14528510/Prevalence_of_antibodies_against_alpha_fodrin_in_Sjögren's_syndrome:_comparison_of_2_sets_of_classification_criteria_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=14528510 DB - PRIME DP - Unbound Medicine ER -