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Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy.
Am J Physiol Endocrinol Metab 2004; 286(2):E261-71AJ

Abstract

The lipodystrophy syndrome (adipose tissue redistribution and metabolic abnormalities) observed with highly active antiretroviral therapy (HAART) during human immunodeficiency virus (HIV) infection may be related to increased proinflammatory cytokine activity. We measured acute cytokine (TNF-alpha, IL-6, leptin), glycerol, and lactate secretion from abdominal subcutaneous adipose tissue (SAT), and systemic cytokine levels, in HIV-infected subjects with and without lipodystrophy (HIVL+ and HIVL-, respectively) and healthy non-HIV controls. Lipodystrophy was confirmed and characterized as adipose tissue redistribution in HIVL+ compared with HIVL- and controls, by dual-energy X-ray absorptiometry and by whole body MRI. TNF-alpha secretion from abdominal SAT and circulating levels of IL-6, soluble TNF receptors I and II, and insulin were elevated in HIVL+ relative to HIVL- and/or controls, particularly in HIVL+ undergoing HAART. In the HIV-infected group as a whole, IL-6 secretion from abdominal SAT and serum IL-6 were positively associated with visceral fat and were negatively associated with the relative amount of lower limb adipose tissue (P < 0.01). Decreased leptin and increased lactate secretion from abdominal SAT were specifically associated with HAART. In conclusion, increased cytokine secretion from adipose tissue and increased systemic proinflammatory cytokine activity may play a significant role in the adipose tissue remodeling and/or the metabolic abnormalities associated with the HIV-lipodystrophy syndrome in patients undergoing HAART.

Authors+Show Affiliations

Obesity Research Center, St. Luke's Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA. JAJohnso33@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14532165

Citation

Johnson, Julia A., et al. "Increased Systemic and Adipose Tissue Cytokines in Patients With HIV-associated Lipodystrophy." American Journal of Physiology. Endocrinology and Metabolism, vol. 286, no. 2, 2004, pp. E261-71.
Johnson JA, Albu JB, Engelson ES, et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab. 2004;286(2):E261-71.
Johnson, J. A., Albu, J. B., Engelson, E. S., Fried, S. K., Inada, Y., Ionescu, G., & Kotler, D. P. (2004). Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. American Journal of Physiology. Endocrinology and Metabolism, 286(2), pp. E261-71.
Johnson JA, et al. Increased Systemic and Adipose Tissue Cytokines in Patients With HIV-associated Lipodystrophy. Am J Physiol Endocrinol Metab. 2004;286(2):E261-71. PubMed PMID: 14532165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. AU - Johnson,Julia A, AU - Albu,Jeanine B, AU - Engelson,Ellen S, AU - Fried,Susan K, AU - Inada,Yoritaro, AU - Ionescu,Gabriel, AU - Kotler,Donald P, Y1 - 2003/10/07/ PY - 2003/10/9/pubmed PY - 2004/2/28/medline PY - 2003/10/9/entrez SP - E261 EP - 71 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 286 IS - 2 N2 - The lipodystrophy syndrome (adipose tissue redistribution and metabolic abnormalities) observed with highly active antiretroviral therapy (HAART) during human immunodeficiency virus (HIV) infection may be related to increased proinflammatory cytokine activity. We measured acute cytokine (TNF-alpha, IL-6, leptin), glycerol, and lactate secretion from abdominal subcutaneous adipose tissue (SAT), and systemic cytokine levels, in HIV-infected subjects with and without lipodystrophy (HIVL+ and HIVL-, respectively) and healthy non-HIV controls. Lipodystrophy was confirmed and characterized as adipose tissue redistribution in HIVL+ compared with HIVL- and controls, by dual-energy X-ray absorptiometry and by whole body MRI. TNF-alpha secretion from abdominal SAT and circulating levels of IL-6, soluble TNF receptors I and II, and insulin were elevated in HIVL+ relative to HIVL- and/or controls, particularly in HIVL+ undergoing HAART. In the HIV-infected group as a whole, IL-6 secretion from abdominal SAT and serum IL-6 were positively associated with visceral fat and were negatively associated with the relative amount of lower limb adipose tissue (P < 0.01). Decreased leptin and increased lactate secretion from abdominal SAT were specifically associated with HAART. In conclusion, increased cytokine secretion from adipose tissue and increased systemic proinflammatory cytokine activity may play a significant role in the adipose tissue remodeling and/or the metabolic abnormalities associated with the HIV-lipodystrophy syndrome in patients undergoing HAART. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/14532165/Increased_systemic_and_adipose_tissue_cytokines_in_patients_with_HIV_associated_lipodystrophy_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00056.2003?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -