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IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum.
Ann Allergy Asthma Immunol. 2003 Sep; 91(3):280-7.AA

Abstract

BACKGROUND

Alternaria alternata and Cladosporium herbarum are common fungi in outdoor environments, but their clinical significance has not been elucidated in Finland.

OBJECTIVE

To evaluate the prevalence of IgE-mediated allergy and clinical outcomes caused by sensitization to fungal allergens in patients with suspected allergy.

METHODS

Skin prick tests (SPTs) were performed with C. herbarum in 6,376 patients and also with A. alternata in 1,504 of these patients. SPTs were repeated in 40 patients who showed a positive reaction to either allergen using commercial and in-house extracts. The association of SPT with allergen-specific IgE antibodies in serum was evaluated. Seven patients also underwent a conjunctival challenge test with these fungal allergens.

RESULTS

The prevalence of positive SPT results to A. alternata and C. herbarum was low (2.8% and 2.7%, respectively). Among the 40 patients, atopic eczema/dermatitis syndrome was found in 58%, asthma in 44%, and rhinitis in 31%. Most of the patients displayed SPT reactions also to several other fungal allergens, and 75% to 80% showed a positive SPT reaction to allergens of pet animals or pollens. Four patients had a positive reaction to A. alternata and 6 to C. herbarum in the conjunctival challenge test.

CONCLUSION

In the Finnish population with allergic symptoms, IgE-mediated sensitization to 2 common fungal allergens was rare and of minor clinical importance. SPT reactions to fungi are mostly observed in patients with multiple sensitivity to various allergens.

Authors+Show Affiliations

Finnish Institute of Occupational Health, Helsinki, Finland. kari.reijula@ttl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14533661

Citation

Reijula, Kari, et al. "IgE-mediated Allergy to Fungal Allergens in Finland With Special Reference to Alternaria Alternata and Cladosporium Herbarum." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 91, no. 3, 2003, pp. 280-7.
Reijula K, Leino M, Mussalo-Rauhamaa H, et al. IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. Ann Allergy Asthma Immunol. 2003;91(3):280-7.
Reijula, K., Leino, M., Mussalo-Rauhamaa, H., Nikulin, M., Alenius, H., Mikkola, J., Elg, P., Kari, O., Mäkinen-Kiljunen, S., & Haahtela, T. (2003). IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 91(3), 280-7.
Reijula K, et al. IgE-mediated Allergy to Fungal Allergens in Finland With Special Reference to Alternaria Alternata and Cladosporium Herbarum. Ann Allergy Asthma Immunol. 2003;91(3):280-7. PubMed PMID: 14533661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. AU - Reijula,Kari, AU - Leino,Marina, AU - Mussalo-Rauhamaa,Helena, AU - Nikulin,Marjo, AU - Alenius,Harri, AU - Mikkola,Jari, AU - Elg,Peter, AU - Kari,Osmo, AU - Mäkinen-Kiljunen,Soili, AU - Haahtela,Tari, PY - 2003/10/10/pubmed PY - 2003/11/13/medline PY - 2003/10/10/entrez SP - 280 EP - 7 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 91 IS - 3 N2 - BACKGROUND: Alternaria alternata and Cladosporium herbarum are common fungi in outdoor environments, but their clinical significance has not been elucidated in Finland. OBJECTIVE: To evaluate the prevalence of IgE-mediated allergy and clinical outcomes caused by sensitization to fungal allergens in patients with suspected allergy. METHODS: Skin prick tests (SPTs) were performed with C. herbarum in 6,376 patients and also with A. alternata in 1,504 of these patients. SPTs were repeated in 40 patients who showed a positive reaction to either allergen using commercial and in-house extracts. The association of SPT with allergen-specific IgE antibodies in serum was evaluated. Seven patients also underwent a conjunctival challenge test with these fungal allergens. RESULTS: The prevalence of positive SPT results to A. alternata and C. herbarum was low (2.8% and 2.7%, respectively). Among the 40 patients, atopic eczema/dermatitis syndrome was found in 58%, asthma in 44%, and rhinitis in 31%. Most of the patients displayed SPT reactions also to several other fungal allergens, and 75% to 80% showed a positive SPT reaction to allergens of pet animals or pollens. Four patients had a positive reaction to A. alternata and 6 to C. herbarum in the conjunctival challenge test. CONCLUSION: In the Finnish population with allergic symptoms, IgE-mediated sensitization to 2 common fungal allergens was rare and of minor clinical importance. SPT reactions to fungi are mostly observed in patients with multiple sensitivity to various allergens. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/14533661/IgE_mediated_allergy_to_fungal_allergens_in_Finland_with_special_reference_to_Alternaria_alternata_and_Cladosporium_herbarum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)63531-4 DB - PRIME DP - Unbound Medicine ER -