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Dietary manipulation, ethnicity, and serum PSA levels.
Urology 2003; 62(4):677-82U

Abstract

OBJECTIVES

To examine whether a diet low in fat and high in fiber, fruits, and vegetables and ethnicity had any influence on serum prostate-specific antigen (PSA) levels, because serum PSA is a marker for the presence of prostate cancer. The incidence of prostate cancer increases with age, varies by ethnicity, and is greater among men with a first-degree relative who has had the disease. Large international variations in the rates of prostate cancer incidence and mortality, as well as the incidence changes in migrants and their offspring, also suggest that exogenous factors, including diet, have a strong influence on the development of this disease.

METHODS

We used data and blood samples from the Polyp Prevention Trial, a multicenter randomized trial designed to evaluate the impact of a diet low in fat and high in fiber, fruits, and vegetables on the recurrence of colorectal adenomas. Recruitment was from 1991 through 1994. Participants were followed up from their baseline recruitment date for 4 years. From this group, we identified 1100 white men and 97 black men who were 35 years of age or older, did not have prostate cancer, and had serum samples available for study.

RESULTS

At baseline, no difference was present in the fat intake for the black and white men (mean +/- SE, 90 +/- 3.6 g/day and 84 +/- 1.0 g/day, respectively; P = 0.15). The baseline serum PSA levels did not vary by ethnicity. For black men, the mean serum PSA level was 2.2 +/- 0.36 ng/mL compared with 2.0 +/- 0.07 ng/mL for white men (P = 0.64). Although all men assigned to the intervention group markedly reduced their fat intake by approximately 15% and increased their fruit and vegetable intake by approximately 2.25 servings per day, no difference was noted in the kinetics of the serum PSA levels by dietary intervention or race.

CONCLUSIONS

Although ethnic differences in the incidence of prostate cancer are well defined, we found no difference in the baseline fat intake among black and white men that might have contributed to this difference. Serum PSA, a marker often used in early detection programs for prostate cancer, was not associated with manipulation of the amount of fat in the diet, regardless of ethnicity.

Authors+Show Affiliations

Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

14550442

Citation

Eastham, James A., et al. "Dietary Manipulation, Ethnicity, and Serum PSA Levels." Urology, vol. 62, no. 4, 2003, pp. 677-82.
Eastham JA, Riedel E, Latkany L, et al. Dietary manipulation, ethnicity, and serum PSA levels. Urology. 2003;62(4):677-82.
Eastham, J. A., Riedel, E., Latkany, L., Fleisher, M., Schatzkin, A., Lanza, E., & Shike, M. (2003). Dietary manipulation, ethnicity, and serum PSA levels. Urology, 62(4), pp. 677-82.
Eastham JA, et al. Dietary Manipulation, Ethnicity, and Serum PSA Levels. Urology. 2003;62(4):677-82. PubMed PMID: 14550442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary manipulation, ethnicity, and serum PSA levels. AU - Eastham,James A, AU - Riedel,Elyn, AU - Latkany,Lianne, AU - Fleisher,Martin, AU - Schatzkin,Arthur, AU - Lanza,Elaine, AU - Shike,Moshe, AU - ,, PY - 2003/10/11/pubmed PY - 2003/11/8/medline PY - 2003/10/11/entrez SP - 677 EP - 82 JF - Urology JO - Urology VL - 62 IS - 4 N2 - OBJECTIVES: To examine whether a diet low in fat and high in fiber, fruits, and vegetables and ethnicity had any influence on serum prostate-specific antigen (PSA) levels, because serum PSA is a marker for the presence of prostate cancer. The incidence of prostate cancer increases with age, varies by ethnicity, and is greater among men with a first-degree relative who has had the disease. Large international variations in the rates of prostate cancer incidence and mortality, as well as the incidence changes in migrants and their offspring, also suggest that exogenous factors, including diet, have a strong influence on the development of this disease. METHODS: We used data and blood samples from the Polyp Prevention Trial, a multicenter randomized trial designed to evaluate the impact of a diet low in fat and high in fiber, fruits, and vegetables on the recurrence of colorectal adenomas. Recruitment was from 1991 through 1994. Participants were followed up from their baseline recruitment date for 4 years. From this group, we identified 1100 white men and 97 black men who were 35 years of age or older, did not have prostate cancer, and had serum samples available for study. RESULTS: At baseline, no difference was present in the fat intake for the black and white men (mean +/- SE, 90 +/- 3.6 g/day and 84 +/- 1.0 g/day, respectively; P = 0.15). The baseline serum PSA levels did not vary by ethnicity. For black men, the mean serum PSA level was 2.2 +/- 0.36 ng/mL compared with 2.0 +/- 0.07 ng/mL for white men (P = 0.64). Although all men assigned to the intervention group markedly reduced their fat intake by approximately 15% and increased their fruit and vegetable intake by approximately 2.25 servings per day, no difference was noted in the kinetics of the serum PSA levels by dietary intervention or race. CONCLUSIONS: Although ethnic differences in the incidence of prostate cancer are well defined, we found no difference in the baseline fat intake among black and white men that might have contributed to this difference. Serum PSA, a marker often used in early detection programs for prostate cancer, was not associated with manipulation of the amount of fat in the diet, regardless of ethnicity. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/14550442/Dietary_manipulation_ethnicity_and_serum_PSA_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429503005764 DB - PRIME DP - Unbound Medicine ER -