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Changes in serum selenium, copper, zinc levels and cu/zn ratio in patients with pulmonary tuberculosis during therapy.
Biol Trace Elem Res. 2003 Oct; 95(1):65-71.BT

Abstract

The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antituberculosis therapy. Copper (Cu), zinc (Zn), and selenium (Se) are the essential elements that play a crucial role in the immune system. The serum levels of these elements vary in many diseases including tuberculosis. In this study, we investigate whether the serum levels of Cu, Zn, and Se change during antituberculosis therapy. We have included 22 pulmonary tuberculosis cases that were newly diagnosed with positive sputum and 18 healthy subjects. At the beginning and 2 mo after therapy, serum levels of Cu, Zn, and Se were measured by atomic absorption spectrometry. Despite Se and Cu levels not being affected during the treatment, we found that there was a significant increase in the levels of Zn and a decrease in the Cu/Zn ratio. Serum Zn levels and the Cu/Zn ratio could be used as a valuable laboratory tool for the clinicians to assess response to therapy or effectiveness of the ongoing antituberculosis therapy.

Authors+Show Affiliations

Department of Pulmonology, Gazi University, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

14555800

Citation

Ciftci, T Ulukavak, et al. "Changes in Serum Selenium, Copper, Zinc Levels and Cu/zn Ratio in Patients With Pulmonary Tuberculosis During Therapy." Biological Trace Element Research, vol. 95, no. 1, 2003, pp. 65-71.
Ciftci TU, Ciftci B, Yis O, et al. Changes in serum selenium, copper, zinc levels and cu/zn ratio in patients with pulmonary tuberculosis during therapy. Biol Trace Elem Res. 2003;95(1):65-71.
Ciftci, T. U., Ciftci, B., Yis, O., Guney, Y., Bilgihan, A., & Ogretensoy, M. (2003). Changes in serum selenium, copper, zinc levels and cu/zn ratio in patients with pulmonary tuberculosis during therapy. Biological Trace Element Research, 95(1), 65-71.
Ciftci TU, et al. Changes in Serum Selenium, Copper, Zinc Levels and Cu/zn Ratio in Patients With Pulmonary Tuberculosis During Therapy. Biol Trace Elem Res. 2003;95(1):65-71. PubMed PMID: 14555800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in serum selenium, copper, zinc levels and cu/zn ratio in patients with pulmonary tuberculosis during therapy. AU - Ciftci,T Ulukavak, AU - Ciftci,B, AU - Yis,O, AU - Guney,Y, AU - Bilgihan,A, AU - Ogretensoy,M, PY - 2002/11/04/received PY - 2003/01/03/accepted PY - 2003/10/14/pubmed PY - 2004/6/18/medline PY - 2003/10/14/entrez SP - 65 EP - 71 JF - Biological trace element research JO - Biol Trace Elem Res VL - 95 IS - 1 N2 - The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antituberculosis therapy. Copper (Cu), zinc (Zn), and selenium (Se) are the essential elements that play a crucial role in the immune system. The serum levels of these elements vary in many diseases including tuberculosis. In this study, we investigate whether the serum levels of Cu, Zn, and Se change during antituberculosis therapy. We have included 22 pulmonary tuberculosis cases that were newly diagnosed with positive sputum and 18 healthy subjects. At the beginning and 2 mo after therapy, serum levels of Cu, Zn, and Se were measured by atomic absorption spectrometry. Despite Se and Cu levels not being affected during the treatment, we found that there was a significant increase in the levels of Zn and a decrease in the Cu/Zn ratio. Serum Zn levels and the Cu/Zn ratio could be used as a valuable laboratory tool for the clinicians to assess response to therapy or effectiveness of the ongoing antituberculosis therapy. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/14555800/Changes_in_serum_selenium_copper_zinc_levels_and_cu/zn_ratio_in_patients_with_pulmonary_tuberculosis_during_therapy_ L2 - https://dx.doi.org/10.1385/BTER:95:1:65 DB - PRIME DP - Unbound Medicine ER -