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Clinical significance of human intestinal spirochetosis--a morphologic approach.
Infection. 2003 Oct; 31(5):341-9.I

Abstract

Intestinal spirochetosis (IS) is a condition defined morphologically by the presence of spirochetal microorganisms attached to the apical cell membrane of the colonic and rectal epithelium. Intestinal spirochetes comprise a heterogeneous group of bacteria. In humans Brachyspira aalborgi and Brachyspira pilosicoli predominate. Prevalence rates of IS are low where living standards are high, in contrast to poorly developed areas where IS is common. Homosexuals and HIV-infected individuals are at high risk of being colonized. Clinical significance in individual cases has remained unclear up to now. A review of the literature reveals that invasion of spirochetes beyond the surface epithelium is associated with gastrointestinal symptoms which respond to antibiotic treatment (metronidazole), whereas patients lacking this feature are mostly asymptomatic. Homosexual and HIV-positive men are more likely to be symptomatic irrespective of invasion. Rare cases of spirochetemia and multiple organ failure have been reported in critically ill patients.

Authors+Show Affiliations

Institute of Pathology, Kantonsspital Luzern, CH-6000 Luzern 16, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14556061

Citation

Körner, M, and J-O Gebbers. "Clinical Significance of Human Intestinal Spirochetosis--a Morphologic Approach." Infection, vol. 31, no. 5, 2003, pp. 341-9.
Körner M, Gebbers JO. Clinical significance of human intestinal spirochetosis--a morphologic approach. Infection. 2003;31(5):341-9.
Körner, M., & Gebbers, J. O. (2003). Clinical significance of human intestinal spirochetosis--a morphologic approach. Infection, 31(5), 341-9.
Körner M, Gebbers JO. Clinical Significance of Human Intestinal Spirochetosis--a Morphologic Approach. Infection. 2003;31(5):341-9. PubMed PMID: 14556061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of human intestinal spirochetosis--a morphologic approach. AU - Körner,M, AU - Gebbers,J-O, PY - 2002/08/19/received PY - 2003/02/05/accepted PY - 2003/10/14/pubmed PY - 2003/12/10/medline PY - 2003/10/14/entrez SP - 341 EP - 9 JF - Infection JO - Infection VL - 31 IS - 5 N2 - Intestinal spirochetosis (IS) is a condition defined morphologically by the presence of spirochetal microorganisms attached to the apical cell membrane of the colonic and rectal epithelium. Intestinal spirochetes comprise a heterogeneous group of bacteria. In humans Brachyspira aalborgi and Brachyspira pilosicoli predominate. Prevalence rates of IS are low where living standards are high, in contrast to poorly developed areas where IS is common. Homosexuals and HIV-infected individuals are at high risk of being colonized. Clinical significance in individual cases has remained unclear up to now. A review of the literature reveals that invasion of spirochetes beyond the surface epithelium is associated with gastrointestinal symptoms which respond to antibiotic treatment (metronidazole), whereas patients lacking this feature are mostly asymptomatic. Homosexual and HIV-positive men are more likely to be symptomatic irrespective of invasion. Rare cases of spirochetemia and multiple organ failure have been reported in critically ill patients. SN - 0300-8126 UR - https://www.unboundmedicine.com/medline/citation/14556061/Clinical_significance_of_human_intestinal_spirochetosis__a_morphologic_approach_ DB - PRIME DP - Unbound Medicine ER -