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Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia.
JAMA 2003; 290(15):2008-14JAMA

Abstract

CONTEXT

The role of race/ethnicity in survival of children with acute lymphoblastic leukemia (ALL) is unclear, with some studies reporting poorer survival among minority children and others reporting equivalent survival across race/ethnicity in the modern, risk-stratified treatment era.

OBJECTIVE

To investigate the relation between race/ethnicity and survival in a large, population-based analysis of incident ALL cases in the United States. DESIGN, POPULATION, AND SETTING: This study included 4952 individuals diagnosed with ALL between 1973 and 1999 at age 19 years or younger. ALL cases were identified from 9 population-based registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results program.

MAIN OUTCOME MEASURES

Survival probabilities were compared among white, black, Hispanic, Asian/Pacific Islander, and American Indian/Alaskan Native children. Kaplan-Meier curves and proportional hazard ratios from Cox regression analysis were calculated, accounting for treatment era (1973-1982, 1983-1989, and 1990-1999), age at diagnosis (<1, 1-9, and 10-19 years), and sex.

RESULTS

Although overall 5-year survival probabilities improved with each successive treatment era, differences according to race/ethnicity persisted. For 1990-1999, 5-year survival was 84% for white children, 81% for Asian/Pacific Islander children, 75% for black children, and 72% for both American Indian/Alaskan Native children and Hispanic children. The largest difference by race/ethnicity was observed among children diagnosed between ages 1 and 9 years. Compared with white children, after adjusting for treatment era, age at diagnosis, and sex, children of black, Hispanic, and American Indian/Alaskan Native descent had hazard ratios of 1.50 (95% CI, 1.0-2.2; P =.03), 1.83 (95% CI, 1.4-2.4; P<.001), and 1.90 (95% CI, 0.8-4.6; P =.16).

CONCLUSIONS

Black, Hispanic, and American Indian/Alaskan Native children with ALL have worse survival than white and Asian/Pacific Islander children, even in the contemporary treatment era. Future work must delineate the social and biological factors, including any differences in pharmacokinetics associated with chemotherapeutic agents, that account for disparities in outcome.

Authors+Show Affiliations

Division of Pediatric Hematology/Oncology, Yale University, New Haven, Conn, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14559954

Citation

Kadan-Lottick, Nina S., et al. "Survival Variability By Race and Ethnicity in Childhood Acute Lymphoblastic Leukemia." JAMA, vol. 290, no. 15, 2003, pp. 2008-14.
Kadan-Lottick NS, Ness KK, Bhatia S, et al. Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia. JAMA. 2003;290(15):2008-14.
Kadan-Lottick, N. S., Ness, K. K., Bhatia, S., & Gurney, J. G. (2003). Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia. JAMA, 290(15), pp. 2008-14.
Kadan-Lottick NS, et al. Survival Variability By Race and Ethnicity in Childhood Acute Lymphoblastic Leukemia. JAMA. 2003 Oct 15;290(15):2008-14. PubMed PMID: 14559954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia. AU - Kadan-Lottick,Nina S, AU - Ness,Kirsten K, AU - Bhatia,Smita, AU - Gurney,James G, PY - 2003/10/16/pubmed PY - 2003/10/24/medline PY - 2003/10/16/entrez SP - 2008 EP - 14 JF - JAMA JO - JAMA VL - 290 IS - 15 N2 - CONTEXT: The role of race/ethnicity in survival of children with acute lymphoblastic leukemia (ALL) is unclear, with some studies reporting poorer survival among minority children and others reporting equivalent survival across race/ethnicity in the modern, risk-stratified treatment era. OBJECTIVE: To investigate the relation between race/ethnicity and survival in a large, population-based analysis of incident ALL cases in the United States. DESIGN, POPULATION, AND SETTING: This study included 4952 individuals diagnosed with ALL between 1973 and 1999 at age 19 years or younger. ALL cases were identified from 9 population-based registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results program. MAIN OUTCOME MEASURES: Survival probabilities were compared among white, black, Hispanic, Asian/Pacific Islander, and American Indian/Alaskan Native children. Kaplan-Meier curves and proportional hazard ratios from Cox regression analysis were calculated, accounting for treatment era (1973-1982, 1983-1989, and 1990-1999), age at diagnosis (<1, 1-9, and 10-19 years), and sex. RESULTS: Although overall 5-year survival probabilities improved with each successive treatment era, differences according to race/ethnicity persisted. For 1990-1999, 5-year survival was 84% for white children, 81% for Asian/Pacific Islander children, 75% for black children, and 72% for both American Indian/Alaskan Native children and Hispanic children. The largest difference by race/ethnicity was observed among children diagnosed between ages 1 and 9 years. Compared with white children, after adjusting for treatment era, age at diagnosis, and sex, children of black, Hispanic, and American Indian/Alaskan Native descent had hazard ratios of 1.50 (95% CI, 1.0-2.2; P =.03), 1.83 (95% CI, 1.4-2.4; P<.001), and 1.90 (95% CI, 0.8-4.6; P =.16). CONCLUSIONS: Black, Hispanic, and American Indian/Alaskan Native children with ALL have worse survival than white and Asian/Pacific Islander children, even in the contemporary treatment era. Future work must delineate the social and biological factors, including any differences in pharmacokinetics associated with chemotherapeutic agents, that account for disparities in outcome. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/14559954/Survival_variability_by_race_and_ethnicity_in_childhood_acute_lymphoblastic_leukemia_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.290.15.2008 DB - PRIME DP - Unbound Medicine ER -