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Bone marrow core biopsy specimens in AL (primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases.
Am J Clin Pathol. 2003 Oct; 120(4):610-6.AJ

Abstract

We retrospectively reviewed 100 bone marrow core biopsy specimens from patients with AL (primary) amyloidosis. The morphologic and immunohistochemical features were assessed by standard histochemical stains (H&E, periodic acid-Schiff, Congo red) and immunohistochemical stains for light chain immunoglobulins. Bone marrow core biopsy revealed a plasma cell dyscrasia in 83% (lambda, 65; kappa, 18) of cases. Amyloid deposits were observed in 60% of the bone marrow core biopsy specimens and, when present, were detected most often in blood vessel walls only (39/60). However, if present, interstitial amyloid deposition was significantly more associated with patients with a monoclonal kappa light chain gammopathy (P = .04). Through the careful analysis of standard histochemical and immunohistochemical stains, bone marrow core biopsy provides essential diagnostic information in cases of AL amyloidosis.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Amyloid Treatment and Research Program, Boston University School of Medicine, 774 Albany St, Boston, MA 02118, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14560572

Citation

Swan, Niall, et al. "Bone Marrow Core Biopsy Specimens in AL (primary) Amyloidosis. a Morphologic and Immunohistochemical Study of 100 Cases." American Journal of Clinical Pathology, vol. 120, no. 4, 2003, pp. 610-6.
Swan N, Skinner M, O'Hara CJ. Bone marrow core biopsy specimens in AL (primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. Am J Clin Pathol. 2003;120(4):610-6.
Swan, N., Skinner, M., & O'Hara, C. J. (2003). Bone marrow core biopsy specimens in AL (primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. American Journal of Clinical Pathology, 120(4), 610-6.
Swan N, Skinner M, O'Hara CJ. Bone Marrow Core Biopsy Specimens in AL (primary) Amyloidosis. a Morphologic and Immunohistochemical Study of 100 Cases. Am J Clin Pathol. 2003;120(4):610-6. PubMed PMID: 14560572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone marrow core biopsy specimens in AL (primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. AU - Swan,Niall, AU - Skinner,Martha, AU - O'Hara,Carl J, PY - 2003/10/17/pubmed PY - 2003/10/29/medline PY - 2003/10/17/entrez SP - 610 EP - 6 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 120 IS - 4 N2 - We retrospectively reviewed 100 bone marrow core biopsy specimens from patients with AL (primary) amyloidosis. The morphologic and immunohistochemical features were assessed by standard histochemical stains (H&E, periodic acid-Schiff, Congo red) and immunohistochemical stains for light chain immunoglobulins. Bone marrow core biopsy revealed a plasma cell dyscrasia in 83% (lambda, 65; kappa, 18) of cases. Amyloid deposits were observed in 60% of the bone marrow core biopsy specimens and, when present, were detected most often in blood vessel walls only (39/60). However, if present, interstitial amyloid deposition was significantly more associated with patients with a monoclonal kappa light chain gammopathy (P = .04). Through the careful analysis of standard histochemical and immunohistochemical stains, bone marrow core biopsy provides essential diagnostic information in cases of AL amyloidosis. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/14560572/Bone_marrow_core_biopsy_specimens_in_AL__primary__amyloidosis__A_morphologic_and_immunohistochemical_study_of_100_cases_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/PFUG-HBX0-TY20-E08U DB - PRIME DP - Unbound Medicine ER -